Updated: 44 min 58 sec ago
Early career researchers win major European funding
Of 3,500 proposals reviewed by the ERC, only 14% were selected for funding – Cambridge has the highest number of grants of any UK institution.
ERC Starting Grants – totalling nearly €780 million – support cutting-edge research in a wide range of fields, from life sciences and physics to social sciences and humanities.
The awards help researchers at the beginning of their careers to launch their own projects, form their teams and pursue their most promising ideas. Starting Grants amount to €1.5 million per grant for a period of five years but additional funds can be made available.
In total, the grants are estimated to create 3,160 jobs for postdoctoral fellows, PhD students and other staff at host institutions.
Cambridge’s recipients work in a wide range of fields including plant sciences, mathematics and medicine. They are among 494 laureates who will be leading projects at universities and research centres in 24 EU Member States and associated countries. This year, the UK has received grants for 50 projects, Germany 98, France 49, and the Netherlands 51.
Cambridge’s grant recipients for 2024 are:Adrian Baez-Ortega (Dept. of Veterinary Medicine, Wellcome Sanger Institute) for Exploring the mechanisms of long-term tumour evolution and genomic instability in marine transmissible cancers
Claudia Bonfio (MRC Laboratory of Molecular Biology) for Lipid Diversity at the Onset of Life
Tom Gur (Dept. of Computer Science and Technology) for Sublinear Quantum Computation
Leonie Luginbuehl (Dept. of Plant Sciences) for Harnessing mechanisms for plant carbon delivery to symbiotic soil fungi for sustainable food production
Julian Sahasrabudhe (Dept. of Pure Mathematics and Mathematical Statistics) for High Dimensional Probability and Combinatorics
Richard Timms (Cambridge Institute for Therapeutic Immunology and Infectious Disease) for Deciphering the regulatory logic of the ubiquitin system
Hannah Übler (Dept. of Physics) for Active galactic nuclei and Population III stars in early galaxies
Julian Willis (Yusuf Hamied Department of Chemistry) for Studying viral protein-primed DNA replication to develop new gene editing technologies
Federica Gigante (Faculty of History) for Unveiling Networks: Slavery and the European Encounter with Islamic Material Culture (1580– 1700) – Grant hosted by the University of Oxford
Professor Sir John Aston FRS, Pro-Vice-Chancellor for Research at the University of Cambridge, said:
“Many congratulations to the recipients of these awards which reflect the innovation and the vision of these outstanding investigators. We are fortunate to have many exceptional young researchers across a wide range of disciplines here in Cambridge and awards such as these highlight some of the amazing research taking place across the university. I wish this year’s recipients all the very best as they begin their new programmes and can’t wait to see the outcomes of their work.”
Iliana Ivanova, European Commissioner for Innovation, Research, Culture, Education and Youth, said:
“The European Commission is proud to support the curiosity and passion of our early-career talent under our Horizon Europe programme. The new ERC Starting Grants winners aim to deepen our understanding of the world. Their creativity is vital to finding solutions to some of the most pressing societal challenges. In this call, I am happy to see one of the highest shares of female grantees to date, a trend that I hope will continue. Congratulations to all!”
President of the European Research Council, Prof. Maria Leptin, said:
“Empowering researchers early on in their careers is at the heart of the mission of the ERC. I am particularly pleased to welcome UK researchers back to the ERC. They have been sorely missed over the past years. With fifty grants awarded to researchers based in the UK, this influx is good for the research community overall.”
Nine Cambridge researchers are among the latest recipients of highly competitive and prestigious European Research Council (ERC) Starting Grants.
researchFundingClaudia BonfioAdrian Baez-OrtegaLeonie LuginbuehlTom GurRichard TimmsJulian SahasrabudheJulian WillisHannah ÜblerFederica GiganteEuropean Research CouncilDepartment of Computer Science and TechnologyMRC Laboratory of Molecular BiologyDepartment of Veterinary MedicineWellcome Sanger InstituteDepartment of Pure Mathematics and Mathematical StatisticsDepartment of PhysicsDepartment of ChemistryCambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID)School of the Biological SciencesSchool of the Physical SciencesFaculty of HistorySchool of the Humanities and Social SciencesLuginbuehl labPlant roots interacting with arbuscular mycorrhizal fungi. Image: Luginbuehl lab
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Children switch to walking and cycling to school after introduction of London’s Ultra-Low Emission Zone
Car travel contributes to air pollution, a major cause of heart and lung diseases including asthma attacks. Beyond this, it limits children's opportunities for physical activity, hindering their development and mental health, and increasing their risk of obesity and chronic illnesses.
Despite UK guidelines recommending a daily average of 60 minutes of moderate-to-vigorous physical activity for school-aged children and adolescents, less than half (45%) of children aged 5-16 met these levels in 2021. One in three children aged 10-11 in the UK are overweight or obese.
In April 2019, London introduced the ULEZ to help improve air quality by reducing the number of vehicles on the road that do not meet emissions standards. According to Transport for London, the central London ULEZ reduced harmful nitrogen oxides by 35% and particulate matter by 15% in central London within the first 10 months of its introduction.
In a study published today in the International Journal of Behavioral Nutrition and Physical Activity, a team led by researchers at the University of Cambridge and Queen Mary University of London examined the impact of the ULEZ on how children travelled to school. The research was part of the CHILL study (Children’s Health in London and Luton).
The study examined data from almost 2,000 children aged six to nine years attending 84 primary schools in London and the control area, Luton. 44 schools were located with catchment areas within or bordering London’s ULEZ, and these were compared to a similar number in Luton and Dunstable (acting as a comparison group). The inclusion of the comparison site enabled the researchers to draw more robust conclusions and increased confidence in attributing the observed changes to the introduction of the ULEZ.
The researchers collected data from the period June 2018 to April 2019, prior to ULEZ implementation, and again in the period June 2019 to March 2020, the year after implementation of the ULEZ but prior to COVID-19-related school closures.
Among those children in London who travelled by car prior to the introduction of the ULEZ, four in 10 (42%) switched to active modes, while one in 20 (5%) switched from active to inactive modes.
In contrast, only two in ten (20%) children in Luton swapped from car travel to active modes, while a similar number (21%) switched from active to car travel. This means that children in London within the ULEZ were 3.6 times as likely to shift from travelling by car to active travel modes compared to those children in Luton and far less likely (0.11 times) to switch to inactive modes.
The impact of the ULEZ on switching to active travel modes was strongest for those children living more than half a mile (0.78km) from school. This was probably because many children who live closer to school already walked or cycled to school prior to the ULEZ and therefore there was more potential for change in those living further away from their school.
The study’s first author, Dr Christina Xiao from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, said: “The introduction of the ULEZ was associated with positive changes in how children travelled to school, with a much larger number of children moving from inactive to active modes of transport in London than in Luton.
“Given children's heightened vulnerability to air pollution and the critical role of physical activity for their health and development, financial disincentives for car use could encourage healthier travel habits among this young population, even if they do not necessarily target them.”
Joint senior author Dr Jenna Panter from the MRC Epidemiology Unit, University of Cambridge, said: “The previous government was committed to increasing the share of children walking to school by 2025 and we hope the new government will follow suit. Changing the way children travel to school can have significant effects on their levels of physical activity at the same time as bringing other co-benefits like improving congestion and air quality, as about a quarter of car trips during peak morning hours in London are made for school drop-offs.”
After ULEZ was introduced in Central London, the total number of vehicles on the roads fell by 9%, and by one-third (34%) for vehicles that failed to meet the required exhaust emission standards, with no clear evidence of traffic moving instead to nearby areas.
Joint senior author Professor Chris Griffiths from the Wolfson Institute of Population Health, Queen Mary University of London, said: “Establishing healthy habits early is critical to healthy adulthood and the prevention of disabling long term illness, especially obesity and the crippling diseases associated with it. The robust design of our study, with Luton as a comparator area, strongly suggests the ULEZ is driving this switch to active travel. This is evidence that Clean Air Zone intervention programmes aimed at reducing air pollution have the potential to also improve overall public health by addressing key factors that contribute to illness.”
Due to the introduction of COVID-19 restrictions in late March 2020, the study was paused in 2020/2021 and results are only reported for the first year of follow-up. However, as both London and Luton, the study areas, were similarly affected, the researchers believe this disruption is unlikely to have affected the results. The study has restarted following up with the children to examine the longer-term impacts of the ULEZ. This will identify if the changes they observed in the year following the introduction of the ULEZ persist.
The study was conducted in collaboration with Queen Mary University of London, Imperial College, University of Bedfordshire, University of Edinburgh, University of Oxford and University of Southern California and funded by the National Institute for Health and Care Research Public Health Research (NIHR), NIHR Applied Research Collaboration North Thames, and Cambridge Trust.
Reference
Xiao, C et al. Children’s Health in London and Luton (CHILL) cohort: A 12-month natural experimental study of the effects of the Ultra Low Emission Zone on children’s travel to school. IJBNPA; 5 Sept 2024; DOI: 10.1186/s12966-024-01621-7
Four in ten children in Central London who travelled to school by car switched to more active modes of transport, such as walking, cycling, or public transport, following the introduction of the Ultra-Low Emission Zone (ULEZ), according to new research. In the comparison area with no ULEZ, Luton, only two in ten children made this switch over the same period.
Spotlight on public healthchildrenpollutionphysical activityChristina XiaoJenna PanterMedical Research CouncilNational Institute for Health and Care Research (NIHR)School of Clinical MedicineMedical Research Council (MRC) Epidemiology UnitChanging the way children travel to school can have significant effects on their levels of physical activity at the same time as bringing other co-benefits like improving congestion and air qualityJenna PanterMatt BrownULEZ signs (cropped)
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High cholesterol levels at a young age significant risk factor for atherosclerosis
The research also suggests that people who are taking lipid-lowering drugs such as statins to lower their cholesterol levels should remain on them, even if their cholesterol levels have fallen, as stopping treatment could increase their risk of atherosclerosis.
Atherosclerosis is one of the major causes of heart and circulatory disease. It involves the hardening and narrowing of the vessels that carry blood to and from the heart. It is caused by the build-up of abnormal material called plaques – collections of fat, cholesterol, calcium and other substances circulating in the blood.
Atherosclerosis is largely considered a disease of the elderly and so most screening, prevention and intervention programmes primarily target those with high cholesterol levels, generally after the age of 50.
But in a study published today in Nature, a team led by scientists at the University of Cambridge shows that high cholesterol levels at a younger age – particularly if those levels fluctuate – can be even more damaging than high cholesterol levels that only begin in later life.
To study the mechanisms that underlie atherosclerosis, scientists often use animal modes, such as mice. The mice will typically be fed a high fat diet for several weeks as adults to see how this leads to the build up of the plaques characteristic of the condition.
Professor Ziad Mallat and colleagues at the Victor Phillip Dahdaleh Heart and Lung Research Institute at the University of Cambridge decided to explore a different approach – to see whether giving mice the same amount of high fat food but spread over their lifetime changed their atherosclerosis risk.
“When I asked my group and a number of people who are experts in atherosclerosis, no one could tell me what the result would be,” said Professor Mallat, a British Heart Foundation (BHF) Professor of Cardiovascular Medicine.
“Some people thought it would make no difference, others thought it would change the risk. In fact, what we found was that an intermittent high fat diet starting while the mice were still young – one week on, a few weeks off, another week on, and so on – was the worst option in terms of atherosclerosis risk.”
Armed with this information, his team turned to the Cardiovascular Risk in Young Finns Study, one of the largest follow-up studies into cardiovascular risk from childhood to adulthood. Participants recruited in the 1980s returned for follow-up over the subsequent decades, and more than 2,000 of them had received ultrasound scans of their carotid arteries when they were aged around 30 years and again at around 50 years.
Analysing the data, the team found that those participants who had been exposed to high cholesterol levels as children tended to have the biggest build of plaques, confirming the findings in mice.
“What this means is that we shouldn’t leave it until later in life before we start to look at our cholesterol levels,” Professor Mallat said. “Atherosclerosis can potentially be prevented by lowering cholesterol levels, but we clearly need to start thinking about this much earlier on in life than we previously thought.”
The mouse studies showed that fluctuating levels of cholesterol appeared to cause the most damage. Professor Mallat says this could explain why some people who are on statins but do not take them regularly remain at an increased risk of heart attack.
“If you stop and start your statin treatment, your body is being exposed to a yo-yo of cholesterol, which it doesn’t like, and it seems this interferes with your body’s ability to prevent the build-up of plaques,” he added.
The reason why this is so damaging may come down to the effect that cholesterol has on specific types of immune cells known as ‘resident arterial macrophages’. These reside in your arteries, helping them to clear damaged cells and fatty molecules known as lipids, which include cholesterol, and stopping the build-up of plaques.
When the team examined these macrophages in their mouse models, they found that high cholesterol levels – and in particular, fluctuating cholesterol levels – changed them physically and altered the activity of their genes. This meant that the cells were no longer protective, but were instead detrimental, accelerating atherosclerosis.
The research was funded by the British Heart Foundation.
Reference
Takaoka, M et al. Early intermittent hyperlipidaemia alters tissue macrophages to boost atherosclerosis. Nature; 4 Sept 2024; DOI: 10.1038/s41586-024-07993-x
Our risk of developing atherosclerosis – ‘furring’ of the arteries – can begin much earlier in life than was previously thought, highlighting the need to keep cholesterol levels low even when we are young, new research has discovered.
cardiovascular disease (CVD)atherosclerosisanimal researchZiad MallatBritish Heart FoundationSchool of Clinical MedicineVictor Phillip Dahdaleh Heart and Lung Research InstituteDepartment of MedicineAtherosclerosis can potentially be prevented by lowering cholesterol levels, but we clearly need to start thinking about this much earlier on in lifeZiad MallatSolStock (Getty Images)Teenagers eating pizza by the river
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Study reveals ‘patchy and inconsistent’ end-of-life care
These are among the conclusions of Time to Care: findings from a nationally representative survey of experiences at the end of life in England and Wales, a new report funded by end-of-life charity Marie Curie and produced by King’s College London’s Cicely Saunders Institute, Hull York Medical School at University of Hull, and the University of Cambridge.
Time to Care aims to describe the outcomes, experiences, and use of care services by people affected by dying, death, and bereavement in England and Wales. It is the final report from the Marie Curie Better End of life programme.
The report found one in five dying people had no contact with their GP in the last three months of life.
Half of people surveyed (49%) said their dying loved one visited A&E at least once in their final three months of life, and one in eight people who died in hospital had been there less than 24 hours.
Half of respondents (49%) in the study were also unhappy with at least one aspect of the care the person who died received and of those one in eight people made a formal complaint. Fewer than half of respondents said they had a key contact person to co-ordinate their care. This meant responsibility for care fell on informal carers (family and friends), who often felt unprepared and unsupported.
Professor Stephen Barclay, from the Department of Public Health & Primary Care at the University of Cambridge, a researcher on the project and a practicing GP, said: “GPs, Community Nurses and the wider Primary Care Team have a central and often under-recognised role in the care of people approaching and at the end of their lives. But they are under enormous pressure with increasing workloads, diminishing workforces and inadequate investment over recent years.
“Increasing numbers of people have been dying in the community during and following the COVID-19 pandemic, at home or in care homes. This important survey, undertaken at a time when the NHS was beginning to recover from the worst of the pandemic, reveals how clinical teams in all settings are struggling to meet the needs of this vulnerable patient group.
“The out-of-hours period, which comprises two-thirds of the week, is particularly difficult for patients and their families. Across the UK, GPs and Community Nurses want to provide excellent palliative and end of life care, but the necessary ‘time to care’ is currently often squeezed. The new UK Government’s focus on care close to home is welcome. This report highlights the need for a radical repurposing of NHS funding to resource primary care for that ambition to be achieved.”
The research report is based on a survey sent by the Office for National Statistics in 2023 to a nationally representative sample of people who had registered the death of a family member in the prior six to 10 months. Only non-sudden causes of death were included. Responses were received from 1179 people, making this the largest nationally representative post-bereavement survey in England and Wales for a decade.
Professor Katherine Sleeman, from King’s College London and lead researcher on the project, said: “This study reveals patchy and inconsistent provision of care for people approaching the end of life. While there were examples of excellent care - including in the community, in care homes, and in hospitals - the overall picture is of services that are overstretched, and of health and care staff lacking the time they need to consistently provide high-quality care. This means that dying people miss out on treatment and care for their symptoms, and families are left feeling unprepared and unsupported which has lasting emotional repercussions into bereavement.
The researchers say the findings are concerning, considering the ageing population and the expected increase in palliative care needs across the UK. By 2048, there will be an additional 147,000 people in the UK who need palliative care before they die, an increase of 25%.
“Without a corresponding increase in capacity of primary and community care teams to support these people as they approach the end of life, the quality of care is likely to further suffer,” said Professor Sleeman. “It has never been more important to ensure high-quality palliative care for all who need it.”
Annette Weatherley, Marie Curie Chief Nursing Officer, added: “The findings are shocking. Too many people are dying in avoidable pain, struggling with breathlessness and other debilitating symptoms because of the difficulties they face accessing the end-of-life care they need from overstretched GPs and other health and care workers.
“Without urgent action, gaps in access to palliative and end of life care will only grow.
“It is a critical time to improve palliative and end of life care. People at the end of life should be able to have the very best possible care. There is only one chance to get it right at the end of life. Yet, as the evidence shows, too many people are being failed by a system faced with extreme financial and workforce pressures. It’s time for Governments to step up and fix care of the dying.”
Professor Stephen Barclay is a fellow at Emmmanuel College, Cambridge.
Adapted from a press release by Marie Curie
One in three dying people in England and Wales was severely or overwhelmingly affected by pain in the last week of life, with bereaved people reporting how difficult it was to get joined-up support from health and care professionals at home.
dyingStephen BarclayMarie Curie FoundationSchool of Clinical MedicineDepartment of Public Health and Primary CareEmmanuel CollegeThis report highlights the need for a radical repurposing of NHS funding to resource primary care for that ambition to be achievedStephen BarclayAlexander GreyExperimental coloured image of two hands touching
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Anti-inflammatory drug could reduce future heart attack risk
A cancer drug that unlocks the anti-inflammatory power of the immune system could help to reduce the risk of future heart attacks, according to research part-funded by the British Heart Foundation. By repurposing an existing drug, researchers hope it could soon become part of routine treatment for patients after a heart attack.
The findings will be presented at the European Society of Cardiology Congress in London by Dr Rouchelle Sriranjan, NIHR Clinical Lecturer in Cardiology at the University of Cambridge.
High levels of inflammation in blood vessels are linked to an increased risk of heart disease and heart attacks. After a heart attack, the body’s immune response can aggravate existing inflammation, causing more harm and increasing risk even further. However, NICE guidelines don’t currently recommend the use of any anti-inflammatory drugs to reduce future risk.
Now, a team of researchers, led by Dr Joseph Cheriyan from Cambridge University Hospitals NHS Foundation Trust, have found that low doses of an anti-inflammatory drug called aldesleukin, injected under the skin of patients after a heart attack, significantly reduces inflammation in arteries.
The researchers are currently following up patients to investigate the longer-term impact of this fall in inflammation. To date, in the two and a half years after their treatment, there have been no major adverse cardiac events in the group that received aldesleukin, compared to seven in the group that received the placebo.
Professor Ziad Mallat, BHF Professor of Cardiovascular Medicine at the University of Cambridge who developed the trial, said: “We associate inflammation with healing – an inbuilt response that protects us from infection and injury. But it’s now clear that inflammation is a culprit in many cardiovascular conditions.
“Early signs from our ongoing trial suggest that people treated with aldesleukin may have better long-term outcomes, including fewer heart attacks. If these findings are repeated in a larger trial, we’re hopeful that aldesleukin could become part of routine care after a heart attack within five to 10 years.”
Aldesleukin is already used to treat kidney cancer, as high doses stimulate the immune system to attack cancer cells. The Cambridge team previously found that doses one thousand times lower than those used in cancer treatment increased the number of regulatory T cells – a type of anti-inflammatory white blood cell – in patients’ blood compared to a placebo.
In the current trial at Addenbrooke's and Royal Papworth hospitals in Cambridge, 60 patients admitted to hospital with a heart attack or unstable angina received either low dose aldesleukin or placebo. Patients received an injection once a day for the first five days, then once per week over the next seven weeks. Neither the participants nor their doctors knew whether they had received the drug or placebo.
At the end of treatment, Positron Emission Tomography (PET) scans showed that inflammation in the artery involved in patients’ heart attack or angina was significantly lower in the group treated with aldesleukin, compared to those who received the placebo.
The anti-inflammatory effect of aldesleukin appeared even more striking in the most inflamed arteries, leading to a larger reduction in inflammation levels in these vessels and a bigger difference between the two groups by the end of the study.
Dr Sonya Babu-Narayan, Associate Medical Director at the British Heart Foundation and consultant cardiologist said: “Thanks to research, we have an array of effective treatments to help people avoid heart attacks and strokes and save lives. But, even after successful heart attack treatment, unwanted inflammation in the coronary arteries can remain, which can lead to life-threatening complications.
“A treatment to reduce inflammation after a heart attack could be a game-changer. It would help doctors to interrupt the dangerous feedback loop that exacerbates inflammation and drives up risk. This research is an important step towards that treatment becoming a reality.”
The study was predominantly funded by the Medical Research Council, with significant support from the BHF and National Institute for Health and Care Research Cambridge Biomedical Research Centre (NIHR-BRC).
Originally published by the British Heart Foundation.
Repurposed cancer drug helps to calm inflammation in arteries.
cardiovascular disease (CVD)heart attackheartpharmaceuticalZiad MallatJoseph CheriyanRouchelle SriranjanBritish Heart FoundationMedical Research CouncilUK Research and Innovation (UKRI)Victor Phillip Dahdaleh Heart and Lung Research InstituteDepartment of MedicineSchool of Clinical MedicineSebastian Kaulitzki/Science Photo Library via Getty ImagesIllustration of human heart
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Global timber supply threatened as climate change pushes cropland northwards
The sight of vineyards in Britain is becoming more common as hotter summers create increasingly suitable conditions for growing grapes. But behind this success story is a sobering one: climate change is shifting the regions of the world suitable for growing crops.
Researchers at the University of Cambridge have uncovered a looming issue: as the land suitable for producing our food moves northwards, it will put a squeeze on the land we need to grow trees. The timber these trees produce is the basis of much of modern life – from paper and cardboard to furniture and buildings.
They say that the increasing competition between land for timber production and food production due to climate change has, until now, been overlooked – but is set to be an emerging issue as our demand for both continues to increase.
Under the worst-case scenario for climate change, where no action is taken to decarbonise society, the study found that over a quarter of existing forestry land – around 320 million hectares, equivalent to the size of India – will become more suitable for agriculture by the end of the century.
Most forests for timber production are currently located in the northern hemisphere in the US, Canada, China and Russia. The study found that 90% of all current forestry land that will become agriculturally productive by 2100 will be in these four countries.
In particular, tens of millions of hectares of timber-producing land across Russia will become newly suitable for agriculture – more than in the US, Canada and China put together – with conditions becoming favourable for potato, soy, and wheat farming.
“There’s only a finite area of suitable land on the planet where we can produce food and wood - two critical resources for society. As climate change worsens and agriculture is forced to expand northwards, there’s going to be increasing pressure on timber production,” said Dr Oscar Morton, a researcher in the University of Cambridge’s Department of Plant Sciences who co-led the study.
“We’ve got to be thinking fifty years ahead because if we want timber in the future, we need to be planting it now. The trees that will be logged by the end of this century are already in the ground – they’re on much slower cycles than food crops,” said Dr Chris Bousfield, a postdoctoral researcher in the University of Cambridge’s Department of Plant Sciences and co-leader of the study.
Global food demand is projected to double by 2050 as the population grows and becomes more affluent. Global wood demand is also expected to double in the same timeframe, in large part because it is a low-carbon alternative to concrete and steel for construction.
Shifting timber production deeper into boreal or tropical forests are not viable options, because the trees in those regions have stood untouched for thousands of years and logging them would release huge amounts of carbon and threaten biodiversity.
“A major environmental risk of increasing competition for land between farming and forestry is that wood production moves into remaining areas of primary forest within the tropics or boreal zones. These are the epicentres of remaining global wilderness and untouched tropical forests are the most biodiverse places on Earth. Preventing further expansion is critical,” said David Edwards, Professor of Plant Ecology in the University of Cambridge’s Department of Plant Sciences and senior author of the study.
To get their results, the researchers took satellite data showing intensive forestry across the world and overlaid it with predictions of suitable agricultural land for the world’s key crops -including rice, wheat, maize, soy and potato - in the future under various climate change scenarios.
Even in the best-case scenario, where the world meets net zero targets, the researchers say there will still be significant future changes in the regions suitable for timber and crop production.
The study is published today in the journal Nature Climate Change.
Timber production contributes over US $1.5 trillion per year to national economies globally. Heatwaves and associated wildfires have caused huge recent losses of timber forests around the world. Climate change is also driving the spread of pests like the Bark Beetle, which attacks trees.
Climate change is expected to cause areas in the tropics to become too hot and inhospitable for growing food and make large areas of southern Europe much less suitable for food and wood production.
“Climate change is already causing challenges for timber production. Now on top of that, there will be this increased pressure from agriculture, creating a perfect storm of problems,” said Bousfield.
“Securing our future wood supply might not seem as pressing as securing the food we need to eat and survive. But wood is just as integrated within our daily lives and we need to develop strategies to ensure both food and wood security into the future,” said Morton.
Reference:
Bousfield, C.G., et al, ‘Climate change will exacerbate land conflict between agriculture and timber production.’ Nature Climate Change (2024). DOI: 10.1038/s41558-024-02113-z
Climate change will move and reduce the land suitable for growing food and timber, putting the production of these two vital resources into direct competition, a new study has found.
Climate changeEnvironmentforestbiodiversityindustryfood securityGlobal food securityOscar MortonDavid EdwardsChris BousfieldDepartment of Plant SciencesSchool of the Biological SciencesGianluca CerulloTimber/farming contrast in the USA
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Mother’s gut microbiome during pregnancy shapes baby’s brain development
Researchers have compared the development of the fetal brain in mice whose mothers had no bacteria in their gut, to those whose mothers were given Bifidobacterium breve orally during pregnancy, but had no other bacteria in their gut.
Nutrient transport to the brain increased in fetuses of mothers given Bifidobacterium breve, and beneficial changes were also seen in other cell processes relating to growth.
Bifidobacterium breve is a ‘good bacteria’ that occurs naturally in our gut, and is available as a supplement in probiotic drinks and tablets.
Obesity or chronic stress can alter the gut microbiome of pregnant women, often resulting in fetal growth abnormalities. The babies of up to 10% of first-time mothers have low birth weight or fetal growth restriction. If a baby hasn't grown properly in the womb, there is an increased risk of conditions like cerebral palsy in infants and anxiety, depression, autism, and schizophrenia in later life.
These results suggest that improving fetal development - specifically fetal brain metabolism - by taking Bifidobacterium breve supplements while pregnant may support the development of a healthy baby.
The results are published today in the journal Molecular Metabolism.
“Our study suggests that by providing ‘good bacteria’ to the mother we could improve the growth and development of her baby while she’s pregnant,” said Dr Jorge Lopez-Tello, a researcher in the University of Cambridge’s Centre for Trophoblast Research, first author of the report.
He added: “This means future treatments for fetal growth restriction could potentially focus on altering the gut microbiome through probiotics, rather than offering pharmaceutical treatments - with the risk of side effects - to pregnant women.”
“The design of therapies for fetal growth restriction are focused on improving blood flow pathways in the mother, but our results suggest we’ve been thinking about this the wrong way - perhaps we should be more focused on improving maternal gut health,” said Professor Amanda Sferruzzi-Perri, a researcher in the University of Cambridge’s Centre for Trophoblast Research and senior author of the report, who is also a Fellow of St John’s College, Cambridge.
She added: “We know that good gut health - determined by the types of microbes in the gut - helps the body to absorb nutrients and protect against infections and diseases.”
The study was carried out in mice, which allowed the effects of Bifidobacterium breve to be assessed in a way that would not be possible in humans - the researchers could precisely control the genetics, other microorganisms and the environment of the mice. But they say the effects they measured are likely to be similar in humans.
They now plan further work to monitor the brain development of the offspring after birth, and to understand how Bifidobacterium breve interacts with the other gut bacteria present in natural situations.
Previous work by the same team found that treating pregnant mice with Bifidobacterium breve improves the structure and function of the placenta. This also enables a better supply of glucose and other nutrients to the developing fetus and improves fetal growth.
“Although further research is needed to understand how these effects translate to humans, this exciting discovery may pave the way for future clinical studies that explore the critical role of the maternal microbiome in supporting healthy brain development before birth,” said Professor Lindsay Hall at the University of Birmingham, who was also involved in the research.
While it is well known that the health of a pregnant mother is important for a healthy baby, the effect of her gut bacteria on the baby’s development has received little attention.
Reference
Lopez-Tello, J., et al: ‘Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice.’ Molecular Metabolism, August 2024. DOI: 10.1016/j.molmet.2024.102004
A study in mice has found that the bacteria Bifidobacterium breve in the mother’s gut during pregnancy supports healthy brain development in the fetus.
pregnancyAmanda Sferruzzi-PerriJorge Lopez-TelloUniversity of BirminghamCentre for Trophoblast ResearchDepartment of Physiology, Development and Neuroscience (PDN)St John's CollegeSchool of the Biological SciencesAsiaVision on Getty
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Red and processed meat consumption associated with higher type 2 diabetes risk
The findings are published today in The Lancet Diabetes and Endocrinology.
Global meat production has increased rapidly in recent decades and meat consumption exceeds dietary guidelines in many countries. Earlier research indicated that higher intakes of processed meat and unprocessed red meat are associated with an elevated risk of type 2 diabetes, but the results have been variable and not conclusive.
Poultry such as chicken, turkey, or duck is often considered to be an alternative to processed meat or unprocessed red meat, but fewer studies have examined the association between poultry consumption and type 2 diabetes.
To determine the association between consumption of processed meat, unprocessed red meat and poultry and type 2 diabetes, a team led by researchers at the University of Cambridge used the global InterConnect project to analyse data from 31 study cohorts in 20 countries. Their extensive analysis took into account factors such as age, gender, health-related behaviours, energy intake and body mass index.
The researchers found that the habitual consumption of 50 grams of processed meat a day - equivalent to 2 slices of ham - is associated with a 15% higher risk of developing type 2 diabetes in the next 10 years. The consumption of 100 grams of unprocessed red meat a day - equivalent to a small steak - was associated with a 10% higher risk of type 2 diabetes.
Habitual consumption of 100 grams of poultry a day was associated with an 8% higher risk, but when further analyses were conducted to test the findings under different scenarios the association for poultry consumption became weaker, whereas the associations with type 2 diabetes for each of processed meat and unprocessed meat persisted.
Professor Nita Forouhi of the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, and a senior author on the paper, said: “Our research provides the most comprehensive evidence to date of an association between eating processed meat and unprocessed red meat and a higher future risk of type 2 diabetes. It supports recommendations to limit the consumption of processed meat and unprocessed red meat to reduce type 2 diabetes cases in the population.
“While our findings provide more comprehensive evidence on the association between poultry consumption and type 2 diabetes than was previously available, the link remains uncertain and needs to be investigated further.”
InterConnect uses an approach that allows researchers to analyse individual participant data from diverse studies, rather than being limited to published results. This enabled the authors to include as many as 31 studies in this analysis, 18 of which had not previously published findings on the link between meat consumption and type 2 diabetes. By including this previously unpublished study data the authors considerably expanded the evidence base and reduced the potential for bias from the exclusion of existing research.
Lead author Dr Chunxiao Li, also of the MRC Epidemiology Unit, said: “Previous meta-analysis involved pooling together of already published results from studies on the link between meat consumption and type 2 diabetes, but our analysis examined data from individual participants in each study. This meant that we could harmonise the key data collected across studies, such as the meat intake information and the development of type 2 diabetes.
“Using harmonised data also meant we could more easily account for different factors, such as lifestyle or health behaviours, that may affect the association between meat consumption and diabetes.”
Professor Nick Wareham, Director of the MRC Epidemiology Unit, and a senior author on the paper said: “InterConnect enables us to study the risk factors for obesity and type 2 diabetes across populations in many different countries and continents around the world, helping to include populations that are under-represented in traditional meta-analyses.
“Most research studies on meat and type 2 diabetes have been conducted in USA and Europe, with some in East Asia. This research included additional studies from the Middle East, Latin America and South Asia, and highlighted the need for investment in research in these regions and in Africa.”
InterConnect was initially funded by the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 602068.
Reference
Li, C et al. Meat consumption and incident type 2 diabetes: a federated meta-analysis of 1·97 million adults with 100,000 incident cases from 31 cohorts in 20 countries. Lancet Diabetes Endocrinol.; 20 August 2024
Adapted form a press release from the MRC Epidemiology Unit
Meat consumption, particularly consumption of processed meat and unprocessed red meat, is associated with a higher type 2 diabetes risk, an analysis of data from almost two million participants has found.
diabetesSpotlight on public healthNita ForouhiChunxiao LiNick WarehamEuropean Union Seventh Framework ProgrammeSchool of Clinical MedicineMedical Research Council (MRC) Epidemiology UnitCambridge Public HealthOur research supports recommendations to limit the consumption of processed meat and unprocessed red meat to reduce type 2 diabetes cases in the populationNita ForouhiRichard BellFull English breakfast
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New way to extend ‘shelf life’ of blood stem cells will improve gene therapy
Researchers have identified a drug already used for cancer patients, that, when applied to current gene therapy protocols can improve blood stem cell function threefold.
One trillion blood cells are produced every day in humans, and blood stem cells are the only cell types in our body capable of producing all blood cell types over our lifespan, giving them immense regenerative potential.
Blood stem cell gene therapy is a ground-breaking treatment that currently provides the only cure to more than ten life-debilitating genetic diseases and has already saved the lives of more than two million people with blood cancers and other diseases.
These therapies take blood stem cell samples from patients, where their genetic defect is corrected in a dish before being delivered back to the patient. However, limitations persist in blood stem cell therapies because of the shelf life of the cells outside the body. When removed from their environment in the human body and cultured in a dish, most blood stem cells lose their function. The exact timing and cause of this function loss has not previously been well understood.
Now, scientists in the Laurenti Group and others at the University of Cambridge’s Cambridge Stem Cell Institute (CSCI) and Department of Haematology have pinpointed a timeline for the blood stem cells under the current gene therapy protocols, which typically take place over three days. After the first 24 hours in a dish, more than 50% of the blood stem cells can no longer sustain life-long blood production, which is before therapy would even begin in a clinical setting.
During those first 24 hours, the cells activate a complex molecular stress response in order to adapt to the dish. By studying this stress response, the team identified a solution. Through repurposing a cancer growth blocker drug (Ruxolitinib), already in use for cancer treatments, they were able to improve stem cell function in a dish by three times its former capabilities.
The group is now aiming to modify current gene therapy protocols to include this drug, providing patients with the highest number of high-quality blood stem cells and improving their outcomes.
The study is published today in the journal Blood.
Professor Elisa Laurenti at the University of Cambridge Stem Cell Institute, and senior author of the study, said: “This is really exciting because we are now in a position where we can begin to understand the huge stress that these stem cells sense when they are manipulated outside of our body. Biologically it is really fascinating because it affects every aspect of their biology. Luckily, we were able to identify a key molecular pathway which governs many of these responses, and that can be targeted by a drug which is already in use and is safe to use.
“I hope our findings will enable safer treatments for gene therapy patients. Our discovery also opens up many possibilities to better expand blood stem cells ex vivo and expand the set of disease where we can use blood stem cells to improve patients’ lives.”
Dr Carys Johnson at the University of Cambridge Stem Cell Institute, and first author of the study, said: “Although we expected that removing these cells from the body and culturing them on a plastic surface would alter gene expression, the extent of change we found was surprising, with over 10,000 genes altered and a significant stress response detected. It was also striking to discover that the majority of blood stem cells are functionally lost during gene therapy protocols, before transplantation back to the patient.
“We have identified a key bottleneck where function is lost and clinical culture could be improved. I hope that our work will drive advancements in culture protocols to better harness the power of blood stem cells and improve the safety and efficacy of clinical approaches.”
Reference
C.S. Johnson, M.J. Williams, K. Sham, et al. ‘Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of cell cycle.’ Blood 2024; DOI: 10.1182/blood.2023021426
Story written by Laura Puhl, Cambridge Stem Cell Institute.
Researchers have discovered a way to extend the shelf life of blood stem cells outside the body for use in gene therapy, providing patients with better options and improving their outcomes.
stem cellsCancerElisa LaurentiCarys JohnsonCambridge Stem Cell InstituteDepartment of HaematologySchool of Clinical MedicineWe were able to identify a key molecular pathway...that can be targeted by a drug which is already in use and is safe to use.Elisa LaurentiPhilippe Delavie from Pixabay
The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.
One in four patients in vegetative or minimally conscious state able to perform cognitive tasks, study finds
Severe brain injury can leave individuals unable to respond to commands physically, but in some cases they are still able to activate areas of the brain that would ordinarily play a role in movement. This phenomenon is known as ‘cognitive motor dissociation’.
To determine what proportion of patients in so-called ‘disorders of consciousness’ experience this phenomenon – and help inform clinical practice – researchers across Europe and North America recruited a total of 353 adults with disorders of consciousness, including the largest cohort of 100 patients studied at Cambridge University Hospitals NHS Foundation Trust.
Participants had mostly sustained brain injury from severe trauma, strokes or interrupted oxygen supply to the brain after heart attacks. Most were living in specialised long-term care facilities and a few were living at home with extensive care packages. The median time from injury for the whole group was about eight months.
Researchers assessed patterns of brain activation among these patients using functional magnetic resonance imaging (fMRI) or electroencephalography (EEG). Subjects were asked to repeatedly imagine performing a motor activity (for example, “keep wiggling your toes”, “swinging your arm as if playing tennis”, “walking around your house from room to room”) for periods of 15 to 30 seconds separated by equal periods of rest. To be able to follow such instructions requires not only the understanding of and response to a simple spoken command, but also more complex thought processes including paying attention and remembering the command.
The results of the study are published today in the New England Journal of Medicine.
Dr Emmanuel Stamatakis from the Department of Clinical Neurosciences at the University of Cambridge said: “When a patient has sustained a severe brain injury, there are very important, and often difficult, decisions to be made by doctors and family members about their care. It’s vitally important that we are able to understand the extent to which their cognitive processes are still functioning by utilising all available technology.”
Among the 241 patients with a prolonged disorder of consciousness, who could not make any visible responses to bedside commands, one in four (25%) was able to perform cognitive tasks, producing the same patterns of brain activity recorded with EEG and/or fMRI that are seen in healthy subjects in response to the same instructions.
In the 112 patients who did demonstrate some motor responses to spoken commands at the bedside, 38% performed these complex cognitive tasks during fMRI or EEG. However, the majority of these patients (62%) did not demonstrate such brain activation. This counter-intuitive finding emphasises that the fMRI and EEG tasks require patients to have complex cognitive abilities such as short-term memory and sustained concentration, which are not required to the same extent for following bedside commands.
These findings are clinically very important for the assessment and management of the estimated 1,000 to 8,000 individuals in the UK in the vegetative state and 20,000 to 50,000 in a minimally conscious state. The detection of cognitive motor dissociation has been associated with more rapid recovery and better outcomes one year post injury, although the majority of such patients will remain significantly disabled, albeit with some making remarkable recoveries.
Dr Judith Allanson, Consultant in Neurorehabilitation, said: “A quarter of the patients who have been diagnosed as in a vegetative or minimally conscious state after detailed behavioural assessments by experienced clinicians, have been found to be able to imagine carrying out complex activities when specifically asked to, is sobering. This sobering fact suggests that some seemingly unconscious patients may be aware and possibly capable of significant participation in rehabilitation and communication with the support of appropriate technology.
“Just knowing that a patient has this ability to respond cognitively is a game changer in terms of the degree of engagement of caregivers and family members, referrals for specialist rehabilitation and best interest discussions about the continuation of life sustaining treatments.”
The researchers caution that care must be taken to ensure the findings are not misrepresented, pointing out, for example, that a negative fMRI/EEG result does not per se exclude cognitive motor dissociation as even some healthy volunteers do not show these responses.
Professor John Pickard, emeritus professorial Fellow of St Catharine's College, Cambridge, said: “Only positive results – in other words, where patients are able to perform complex cognitive processes – should be used to inform management of patients, which will require meticulous follow up involving specialist rehabilitation services.”
The team is calling for a network of research platforms to be established in the UK to enable multicentre studies to examine mechanisms of recovery, develop easier methods of assessment than task-based fMRI/EEG, and to design novel interventions to enhance recovery including drugs, brain stimulation and brain-computer interfaces.
The research reported here was primarily funded by the James S. McDonnell Foundation. The work in Cambridge was supported by the National Institute for Health and Care Research UK, MRC, Smith’s Charity, Evelyn Trust, CLAHRC ARC fellowship and the Stephen Erskine Fellowship (Queens’ College).
Reference
Bodien, YG et al. Cognitive Motor Dissociation in Disorders of Consciousness. NEJM; 14 Aug 2024; DOI: 10.1056/NEJMoa2400645
Adapted from a press release from Weill Cornell Medicine
Around one in four patients with severe brain injury who cannot move or speak – because they are in a prolonged coma, vegetative or minimally conscious state – is still able to perform complex mental tasks, a major international study has concluded in confirmation of much smaller previous studies.
Spotlight on neuroscienceEmmanuel StamatakisJohn PickardJudith AllansonJames S McDonnell FoundationNational Institute for Health Research (NIHR)Medical Research CouncilEvelyn TrustNIHR CLAHRC for Cambridgeshire and Peterborough NHS Foundation TrustSchool of Clinical MedicineDepartment of Clinical NeurosciencesDivision of AnaesthesiaQueens' CollegeSt Catharine's CollegeWhen a patient has sustained a severe brain injury, there are very important, and often difficult, decisions to be made by doctors and family members about their careEmmanuel StamatakisWitthaya Prasongsin (Getty Images)Male patient in a hospital bed - stock imageAcknowledgementsThe multidisciplinary Cambridge Impaired Consciousness Research Group, led by Emeritus Professors John Pickard (Neurosurgery) & David Menon (Anaesthesia) and Drs Judith Allanson & Emmanuel A. Stamatakis (Lead, Cognition and Consciousness Imaging Group), started its research programme in 1997, partly in response to emerging concern over the misdiagnosis of the vegetative state. This pioneering work has only been possible by having access to the world class resources of the Wolfson Brain Imaging Centre, the NIHR/Wellcome Clinical Research Facility at Addenbrooke’s Hospital, the MRC Cognition and Brain Sciences Unit (Professors Barbara Wilson & Adrian Owen), the Royal Hospital for Neuro-disability (Putney) and the Central England Rehabilitation Unit (Royal Leamington Spa).
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Combined forces
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Combined forces
Shorthand Story Body:
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Combined forces
How a partnership of scientists, patients and industry could transform prostate cancer care
New, repurposed and combined treatments could soon transform prostate cancer outcomes, with DNA repair research informing promising clinical trials at Cambridge.
Prostate cancer is the most common cancer in men in 112 countries, and accounts for 15% of all cancers. Worldwide, 375,000 men died from the cancer in 2020. Only lung cancer ranks higher in terms of cancer mortality among men. The Lancet recently estimated that new cases will rise to 2.9 million by 2040 from 1.4 million in 2020.
The prostate gland sits at the base of the bladder. Cancers begin in the prostate’s lining epithelium and range from low-grade tumours that don’t require treatment to rapidly growing, lethal cancers. The biology behind this spectrum of cancer behaviour is only partially understood.
Andrew Pickering is raring to go. He’s young (not quite 61), fit and has a busy life being a self-employed interior design consultant, as well as being married with three sons and three grandchildren. But a few months ago, he had surgery for prostate cancer and he’s been forced to rest.Men like Andrew hold vital information to change the story of prostate cancer for good. But men in his position aren’t always keen to take part in clinical trials, less because they fear side-effects, more because it’s one more thing to think about, and they don’t want to delay getting back to normal.
When he was invited, Andrew immediately agreed to take part and has no regrets. “There are limited numbers of people who can go on these trials. I felt it was the right thing for me to do. It's no good just having things in a laboratory. We need to try out treatments in people. It was no hardship at all."
“It was made clear to me that I wouldn’t benefit personally. That’s fine – if it can help people in the future, then great. I hope my sons never get cancer, but I wanted to support the research that might help them if they ever did.”Andrew Pickering
Andrew is part of ASCERTAIN, a study which is investigating the biological effects of a new PARP inhibitor, an existing hormone treatment, and a combination of the two, on men with newly diagnosed prostate cancer.
For Andrew, this meant taking a pill once daily for three weeks between his diagnosis and prostatectomy. He has also been undergoing ECG, blood and urine checks since his operation at Addenbrooke’s Hospital in Cambridge.
Andrew Pickering with his wife Claire
Andrew Pickering with his wife Claire
ASCERTAIN is one of a number of ‘window-of-opportunity’ prostate cancer studies being run collaboratively by two University of Cambridge teams in partnership with AstraZeneca. It’s a multinational study involving colleagues in Europe, North America and Australia, with Cambridge as the joint lead.
These studies collect tumour biopsies before and after the investigational treatment to identify any impact on cancer cells of giving one or more drugs. At the same time, the researchers carefully assess patients for any side-effects.
Central to this work is the partnership of two teams led by Dr Harveer (Harvey) Dev and Dr Simon Pacey. Dev is a urologist, surgeon and lead for a surgical translational research group at Cambridge’s Early Cancer Institute. Pacey is a medical oncologist and an experienced investigator in early drug development. Both represent the University of Cambridge’s Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, and Cancer Research UK.
Together, Dev and Pacey aim to exploit genetic vulnerabilities in prostate cancer to redeploy existing treatments and help develop new drugs.
Attacking cancer's Achilles heelDNA repair is so important to our cells that we have evolved several methods of repairing damage. One of these involves an enzyme known as PARP, but there is a backup process known as homologous recombination that steps in should this method fail.
Cancer cells that harbour genetic alterations such as BRCA1 or BRCA2 mutations are unable to carry out homologous recombination. Cambridge scientist Professor Sir Steve Jackson realised that inhibiting PARP in these cells meant they had no way of repairing themselves and they would die off – he had found their Achilles heel.
“This really is one of those golden bullet therapies which target the cancer cells and spare the healthy cells around them.”Harvey Dev
The benefits of PARP inhibitors for patients with BRCA and other mutations are well known, but Dev and Pacey’s work suggests that these benefits could be increased and more surprisingly, extended to the far larger group of patients who do not have homologous recombination repair gene defects.
In their previous work, Pacey and Dev have assessed the effects of giving an approved potent inhibitor of PARP enzymes, to patients for two weeks prior to prostatectomy. Half of these participants were also randomly allocated to an anti-androgen hormone treatment, which lowers testosterone levels. Analysis of biopsy and prostatectomy samples showed that inhibiting PARP enzymes contributes to a significant impact on the cancer cells even in some patients with no known gene mutations such as BRCA2.
The researchers found molecular evidence of drug effect in prostate cancer cells. The study also revealed several unique effects of combination treatment that were not as strongly observed with the PARP enzyme inhibitor alone, or in a separate study involving anti-androgen therapy. This includes changes in the expression of various pathways, including those involved in cell turnover and inflammation; these could help to explain why the combination treatment may be effective in a wider group of patients.
Crucially, both experimental treatments were well tolerated by all participants and had no impact on their planned operations or subsequent recovery.
NICE (the National Institute for Health and Care Excellence) recently approved the utilisation of the PARP enzyme inhibitor with drugs that block testosterone effects in patients with metastatic prostate cancer. Dev and Pacey want to understand this better and to see if the treatment could be repurposed at earlier stages of prostate cancer, to help many more men.
“Why would individuals without those DNA repair gene defects benefit from a therapy that works entirely through that mechanism? That’s what our lab is working on.”Harvey Dev
“We’re interrogating the genetic drivers that underpin these processes and we've identified a few candidates that we think are important. We’re looking into novel markers which could be unrelated to the cascade of functions that BRCA is involved with but which we think are functionally relevant to how these drugs cooperate.”
The androgen receptor, the main hormone driver in cancer cells, is somehow contributing to the DNA repair process and it is through the combination of targeting that pathway and boosting the sensitivity of cancer cells to treatments that Dev and Pacey believe a breakthrough could be made.
Dev says: “As we start to validate our findings, we can go back to patients and look for those markers and see whether we've now identified another group of individuals who would benefit from combination treatment.”
Harvey Dev
Harvey Dev
The power of partnershipSimon Pacey
Simon Pacey
Pacey says: “For clinical trials to work best, you need collaboration with a translational lab like Harvey’s, critically supported by patients who wish to take part. Working with Harvey focuses the mind. We all have a shared interest in DNA repair and we’re looking for opportunities to convert discoveries in this area into developing effective treatments.
“We’re in a great place on this campus. It is quite unique that we can bring together surgery, radiotherapy, oncology, pathology and radiology experts to develop treatments for earlier onset patients to help them live much longer. And we’re right next to the biopharma company, AstraZeneca, which is world class at developing PARP inhibitors and DNA repair inhibitors.”
Cambridge Biomedical Campus
Cambridge Biomedical Campus
Pacey focuses his efforts on drugs in early development because, he says, they “offer a sweet spot to do something impactful in the lab and make a difference down the line for patients. I like what I do because the small scale of the studies makes it agile.”
Both Dev and Pacey can’t emphasise enough the importance of collaborating with trial participants like Andrew Pickering.
“We currently don't have great models for prostate cancer. The best model is human cancer itself."Simon Pacey
"So we rely on these pre-surgical, window-of-opportunity studies. We rely on our patients giving us their time completely altruistically. My job is then to design a study to answer key questions while minimising the risk of side effects. I can’t get that risk down to zero but that’s what I’m aiming for so that men can undergo their planned surgery on time.
“We've got a really good track record in Cambridge of recruiting men to take part in these window studies, which is no small feat because the team might have to approach 200 men to recruit just 20.”
Andrew says: “During the trial you are monitored very closely. Even if the trial drugs had side effects or were found to be harmful in any way at all, I'm certain that it would be picked up very quickly and addressed. Having that attention is really reassuring. The care given by the doctors and nurses, who are working as part of the trial team, is second to none.”
Dev adds: “Most of what we do wouldn't be achievable without patients volunteering for the benefit of others in the future. It hits me with every patient interaction that we need to work fast to make a clinical impact now, rather than in 20 years’ time. This motivation really feeds into the very DNA of our new Early Cancer Institute. Physicists, engineers and mathematicians continue to make critical contributions to our research but we are also heavily and unapologetically clinical, and extremely aware of the need to accelerate our research efforts to help the very patients that we see every day.”
Fresh approaches Both men are impatient for progress.“Survival for later stage prostate cancer has improved due to new drugs being approved,” Pacey says, “but there’s a lot of room for improvement because men still aren’t living that much longer, compared to progress in some other cancers.”
“We now have the cellular and molecular technologies to look at cancers in much better detail but we’re not doing enough of that for prostate cancer yet. We’re five to 10 years away from having a lot more information than we do now for each patient. And then I think prostate cancer will move from a one-size-fits-all to increasingly be able to segment patients as we do with other cancers and having more personalised approaches.”
Cambridge Cancer Research Hospital, expected to open in 2029, will be a natural home for these fresh approaches.
Dev says: “The aim with the new hospital is to bring clinical translational research to the frontline so that we can have a faster and greater impact on our patients. And at the same time, patients will be providing the samples which advance our research into, for instance, early signals of cancer.
“We’re currently building the business case for the nation’s first molecular prostate clinic for early cancers. In the first instance, our vision is to bring genomic testing to all men in the East of England who have a newly diagnosed prostate cancer because of BRCA and other mutations. They aren’t being evaluated right now because of limitations in the existing infrastructure.”
Andrew Pickering is back to work now.
“I'm glad to get back into my routine,” he says. “I never imagined I would get prostate cancer. I noticed that I was having to go to the toilet more often than I used to, but I just put it down to getting older. It was only when I mentioned it at a routine health check that the nurse suggested that it might not be old age, and that it would be worth getting my prostate checked. The rest is history and how I find myself here today!"
It’s a familiar story. What results from the research that he and others are now making possible may not be. Support cancer research at CambridgeCambridge hosts a cancer research community responsible for globally significant breakthroughs and innovations.
Together we are changing the way cancer is treated. Our scientists will make discoveries alongside expert clinicians treating patients, drawing on the world-leading expertise found within the University and across the Cambridge Biomedical Campus.
We will find cancer earlier and treat it better. Join us. Donate nowPublished 13 August 2024
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- Main image: Prostate cancer cells by Annie Cavanagh / Wellcome Collection)
- Harvey Dev and Simon Pacey by Lloyd Mann
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TopBuilt with Shorthand { setTimeout(() => { document.querySelectorAll('#main a').forEach(link => link.classList.remove('campl-external')); }, 2050); }); //--> Summary:New, repurposed and combined treatments could soon transform prostate cancer outcomes, with DNA repair research informing promising clinical trials at Cambridge.
Image: Affiliation (schools and institutions): School of Clinical MedicineCancer Research UK Cambridge CentreCambridge Cancer Research HospitalCambridge University Hospitals NHS Foundation TrustExternal Affiliations: Cancer Research UK (CRUK)People (our academics and staff): Harveer DevSimon PaceySubject (including Spotlight on ... where applicable): Cancerprostate cancerSection: ResearchSuper Tags: Health and medicineShorthand Story Description/Subtitle: How a partnership of scientists, patients and industry could transform prostate cancer careShorthand Story Authors: Tom WilliamsShorthand Story Thumbnail: https://www.cam.ac.uk/sites/www.cam.ac.uk/files/shorthand/247371/bW8pB9Qwbt/assets/aF73qlIG4m/prostate-cancer-cells_credit_annie-cavanagh_source_wellcome-collection-land-thumbnail.jpgAdvanced MRI scans help identify one in three concussion patients with ‘hidden disease’
Around one in 200 people in Europe every year will suffer concussion. In the UK, more than 1 million people attend Emergency Departments annually with a recent head injury. It is the most common form of brain injury worldwide.
When a patient in the UK presents at an Emergency Department with head injury, they are assessed according to the NICE head injury guidelines. Depending on their symptoms, they may be referred for a CT scan, which looks for brain injuries including bruising, bleeding and swelling.
However, CT scans identify abnormalities in fewer than one in 10 patients with concussion, yet 30-40% of patients discharged from the Emergency Department following a scan experience significant symptoms that can last for years and be potentially life-changing. These include severe fatigue, poor memory, headaches, and mental health issues (including anxiety, depression, and post-traumatic stress).
Dr Virginia Newcombe from the Department of Medicine at the University of Cambridge and an Intensive Care Medicine and Emergency Physician at Addenbrooke’s Hospital, Cambridge, said: “The majority of head injury patients are sent home with a piece of paper telling them the symptoms of post-concussion to look out for and are told to seek help from their GP if their symptoms worsen.
“The problem is that the nature of concussion means patients and their GPs often don’t recognise that their symptoms are serious enough to need follow-up. Patients describe it as a ‘hidden disease’, unlike, say, breaking a bone. Without objective evidence of a brain injury, such as a scan, these patients often feel that their symptoms are dismissed or ignored when they seek help.”
In a study published today in eClinicalMedicine, Dr Newcombe and colleagues show that an advanced form of MRI known as diffusion tensor imaging (DTI) can substantially improve existing prognostic models for patients with concussion who have been given a normal CT brain.
DTI measures how water molecules move in tissue, providing detailed images of the pathways, known as white matter tracts, that connect different parts of the brain. Standard MRI scanners can be adapted to measure this data, which can be used to calculate a DTI ‘score’ based on the number of different brain regions with abnormalities.
Dr Newcombe and colleagues studied data from more than 1,000 patients recruited to the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study between December 2014 and December 2017. 38% of the patients had an incomplete recovery, meaning that three months after discharge their symptoms were still persisting.
The team assigned DTI scores to the 153 patients who had received a DTI scan. This significantly improved the accuracy of the prognosis – whereas the current clinical model would correctly predict in 69 cases out of 100 that a patient would have a poorer outcome, DTI increased this to 82 cases out of 100.
dti_images_web.jpgWhole brain diffusion tensor tractography showing healthy patient (left) and patient at two days (centre) and six weeks (right) after severe traumatic brain injury (Credit: Virginia Newcombe)
The researchers also looked at blood biomarkers – proteins released into the blood as a result of head injury – to see whether any of these could improve the accuracy of the prognosis. Although the biomarkers alone were not sufficient, concentrations of two particular proteins – glial fibrillary acidic protein (GFAP) within the first 12 hours and neurofilament light (NFL) between 12 and 24 hours following injury – were useful in identifying those patients who might benefit from a DTI scan.
Dr Newcombe said: “Concussion is the number one neurological condition to affect adults, but health services don’t have the resources to routinely bring back every patient for a follow-up, which is why we need a way of identifying those patients at greatest risk of persistent symptoms.
“Current methods for assessing an individual’s outlook following head injury are not good enough, but using DTI – which, in theory, should be possible for any centre with an MRI scanner – can help us make much more accurate assessments. Given that symptoms of concussion can have a significant impact on an individual’s life, this is urgently needed.”
The team plan to look in greater details at blood biomarkers, to see if they can identify new ways to provide even simpler, more practical predictors. They will also be exploring ways to bring DTI into clinical practice.
Dr Sophie Richter, a NIHR Clinical Lecturer in Emergency Medicine and first author, Cambridge, added: “We want to see if there is a way to integrate the different types of information obtained when a patient presents at hospital with brain injury – symptoms assessment, blood tests and brain scans, for example – to improve our assessment of a patient’s injury and prognosis.”
The research was funded by European Union's Seventh Framework Programme, Wellcome and the National Institute for Health and Care Excellence.
Reference
Richter, S et al. Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study. eClinMed; 8 Aug 2024; DOI: 10.1016/j.eclinm.2024.102751
Offering patients with concussion a type of brain scan known as diffusion tensor imaging MRI could help identify the one in three people who will experience persistent symptoms that can be life changing, say Cambridge researchers.
Spotlight on neuroscienceImagingbrain injuryVirginia NewcombeSchool of Clinical MedicineDepartment of Clinical NeurosciencesConcussion is the number one neurological condition to affect adults, which is why we need a way of identifying those patients at greatest risk of persistent symptomsVirginia NewcombeCallista Images (Getty Images)Diffusion tensor imaging (DTI) MRI of the human brain - stock photo
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‘Far from clear’ new Alzheimer’s drugs will make a difference at a population level, say researchers
Writing in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, the team from Cambridge Public Health argue that substantial challenges including the risk-benefit ratio, limited eligibility and high cost of roll-out will limit any benefits of these treatments.
Alzheimer’s disease is often quoted as causing 70% of the 55 million cases of dementia worldwide, though the definition of what constitutes the disease is hotly debated. One characteristic of Alzheimer’s is the build-up of clusters of misfolded proteins, one of these being a form of amyloid, leading to plaques in the brain. The cascade hypothesis, a dominant theory in the field, suggests that this triggers a series of processes which together lead to dementia symptoms.
Advances in developing treatments to reduce symptoms and slow down the progression in the early stages of Alzheimer’s has been slow. However, there has been recent excitement surrounding amyloid immunotherapy agents, drugs that harness the immune system to remove amyloid pathology.
Two completed phase III randomised controlled trials of amyloid immunotherapy reported statistically significant reductions in the rate of cognitive and functional decline compared to the placebo.
But as the Cambridge team point out, the effect sizes were small – small enough that a doctor would struggle to tell the difference between the average decline of a patient on the drug and another on placebo, after 18 months. The drugs were also associated with significant adverse events, including brain swelling and bleeding; during the phase III trial of one agent, donanemab, there were also three deaths attributed to the treatment.
Crucially, there is little known about the long-term effects of the drugs beyond the 18 month trial periods. Long-term placebo-controlled trials, which would be needed to see if there is any clinically meaningful slowing of decline, are unlikely to be feasible where drugs are already approved.
Despite this, the US Food and Drug Administration has licensed two such drugs. The European Medicines Agency (EMA) has recommended rejecting one (lecanemab) predominantly on the grounds that the small effects seen do not outweigh the risk from side effects; it is reviewing the other. The UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) is expected to take a decision on both drugs imminently.
Edo Richard, Professor of Neurology at Radboud University Medical Centre in Nijmegen, The Netherlands, and co-author, said: “If these drugs are approved by regulators in the UK and Europe, and become available, it is understandable that some people with early Alzheimer’s will still want to try these drugs, given their despair living with this dreadful disease. But there is a lot of hyperbole around the reporting of these drugs, and significant effort will be needed to provide balanced information to patients to enable informed decisions.”
Press coverage of the drugs has implied they are suitable for anyone with a diagnosis of Alzheimer’s. However, while the trials included those with ‘early symptomatic Alzheimer’s disease’, it excluded those with other conditions that may have been contributing to their symptoms. Evidence suggests that the people in the trials represent less than 8% of those in the community with early Alzheimer’s disease. Those in the trials were up to 10 to 15 years younger than those typically presenting to health services with early symptoms.
Lead author Dr Sebastian Walsh, NIHR Doctoral Fellow in Public Health Medicine at Cambridge Public Health, University of Cambridge, added: “If approved, the drugs are likely to be relevant only for a relatively small cohort of Alzheimer’s patients, so potential recipients will need to undergo a range of assessments before being given access to the drugs. Plus, effect sizes seen in the trials are very small and the drugs will need be administered as early in the disease process as possible, when symptoms are mild – and people in these phases of disease can be hard to identify.”
The resource requirements for rolling out such treatments are likely to be considerable. Even if approved for only a small proportion of Alzheimer’s patients, a much broader group of people will need to be assessed for eligibility, requiring rapid specialist clinical assessment and tests. The authors question whether this is the best use of these resources, given the strain health systems are already under. Support would also be required for the large number of Alzheimer’s patients (potentially as many as 92%) found to be ineligible. Those found to have insufficient amyloid to be eligible may then require follow-up assessments to determine eligibility in the future, with the further implications for services this would entail.
Professor Carol Brayne, Co-director of Cambridge Public Health, said: “Even in high-income countries, rolling out such types of treatments at scale is highly challenging, but most dementia occurs in low- and middle-income countries. Health systems in these countries are highly unlikely to have the resources required to offer these new drugs, even to a very narrow group.
“Other compelling evidence suggests that attention to inequalities and health experience across people’s lives could have greater impact on the rates of dementia in populations. Most dementia is more complicated than a single protein.”
The team concludes that based on current evidence, it is far from clear whether amyloid immunotherapy can ever significantly reduce suffering caused by dementia at scale in the community, and we must continue to explore other approaches.
Professor Brayne added: “With an ageing population, we urgently need effective ways to support people living with dementia, but while the current amyloid immunotherapies may show a glint of promise for very selected groups, it’s clear these drugs will not address dementia risk at scale.”
Reference
Walsh, S et al. Considering challenges for the new Alzheimer’s drugs: clinical, population, and health system perspectives. Alz&Dem; 6 Aug 2024; DOI: 10.1002/alz.14108
Cambridge researchers have cast doubt on whether new amyloid immunotherapy drugs will have the desired effect of significantly reducing the impact of Alzheimer’s disease.
Spotlight on public healthSpotlight on neuroscienceAlzheimer's diseasedementiaspotlight on future therapeuticsSebastian WalshCarol BrayneSchool of Clinical MedicineCambridge Public HealthWhile the current amyloid immunotherapies may show a glint of promise for very selected groups, it’s clear these drugs will not address dementia risk at scaleCarol BrayneSteven HWG (Unsplash)Woman sitting in a wheelchair
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Scientists discover entirely new wood type that could be highly efficient at carbon storage
Scientists from the Sainsbury Laboratory Cambridge University and Jagiellonian University, Poland made the discovery while undertaking an evolutionary survey of the microscopic structure of wood from some of the world’s most iconic trees and shrubs.
They found that Tulip Trees, which are related to magnolias and can grow over 100 feet tall, have a unique type of wood. This discovery may explain why the trees, which diverged from magnolias when earth's atmospheric CO2 concentrations were relatively low, grow so tall and so fast. This opens new opportunities to improve carbon capture and storage in plantation forests by planting a fast-growing tree more commonly seen in ornamental gardens, or breeding Tulip Tree-like wood into other tree species.
The discovery was part of an evolutionary survey of the microscopic structure of wood from 33 tree species from the Cambridge University Botanic Garden’s Living Collections. The survey explored how wood ultrastructure evolved across softwoods (gymnosperms such as pines and conifers) and hardwoods (angiosperms including oak, ash, birch, and eucalypts).
The wood samples were collected from trees in the Botanic Garden in coordination with its Collections Coordinator. Fresh samples of wood, deposited in the previous spring growing season, were collected from a selection of trees to reflect the evolutionary history of gymnosperm and angiosperm populations as they diverged and evolved.
Using the Sainsbury Laboratory's low temperature scanning electron microscope (cryo-SEM), the team imaged and measured the size of the nanoscale architecture of secondary cell walls (wood) in their native hydrated state.
Microscopy Core Facility Manager at the Sainsbury Laboratory, Dr Raymond Wightman, said: “We analysed some of the world’s most iconic trees like the Coast Redwood, Wollemi Pine and so-called “living fossils” such as Amborella trichopoda, which is the sole surviving species of a family of plants that was the earliest still existing group to evolve separately from all other flowering plants.
“Our survey data has given us new insights into the evolutionary relationships between wood nanostructure and the cell wall composition, which differs across the lineages of angiosperm and gymnosperm plants. Angiosperm cell walls possess characteristic narrower elementary units, called macrofibrils, compared to gymnosperms.”
The researchers found the two surviving species of the ancient Liriodendron genus, commonly known as the Tulip Tree (Liriodendron tulipifera) and Chinese Tulip Tree (Liriodendron chinense) have much larger macrofibrils than their hardwood relatives.
Hardwood angiosperm macrofibrils are about 15 nanometres in diameter and faster growing softwood gymnosperm macrofibrils have larger 25 nanometre macrofibrils. Tulip Trees have macrofibrils somewhere in between, measuring 20 nanometres.
Lead author of the research published in New Phytologist, Dr Jan Łyczakowski from Jagiellonian University, said: “We show Liriodendrons have an intermediate macrofibril structure that is significantly different from the structure of either softwood or hardwood. Liriodendrons diverged from Magnolia Trees around 30-50 million years ago, which coincided with a rapid reduction in atmospheric CO2. This might help explain why Tulip Trees are highly effective at carbon storage.”
The team suspect it is the larger macrofibrils in this “midwood” or “accumulator-wood” that is behind the Tulip Trees’ rapid growth.
Łyczakowski added: “Both Tulip Tree species are known to be exceptionally efficient at locking in carbon, and their enlarged macrofibril structure could be an adaptation to help them more readily capture and store larger quantities of carbon when the availability of atmospheric carbon was being reduced. Tulip Trees may end up being useful for carbon capture plantations. Some east Asian countries are already using Liriodendron plantations to efficiently lock in carbon, and we now think this might be related to its novel wood structure.”
Liriodendron tulipifera are native to northern America and Liriodendron chinense is a native species of central and southern China and Vietnam.
Łyczakowski said: “Despite its importance, we know little about how the structure of wood evolves and adapts to the external environment. We made some key new discoveries in this survey – an entirely novel form of wood ultrastructure never observed before and a family of gymnosperms with angiosperm-like hardwood instead of the typical gymnosperm softwood.
“The main building blocks of wood are the secondary cell walls, and it is the architecture of these cell walls that give wood its density and strength that we rely on for construction. Secondary cell walls are also the largest repository of carbon in the biosphere, which makes it even more important to understand their diversity to further our carbon capture programmes to help mitigate climate change.”
This research was funded by the National Science Centre Poland and The Gatsby Charitable Foundation.
Reference: Lyczakowski, J.L. and Wightman, R. "Convergent and adaptive evolution drove change of secondary cell wall ultrastructure in extant lineages of seed plants." July 2024, New Phytologist. DOI: 10.1111/nph.19983
All cryo-SEM images from the wood survey are publicly available here.
Read more about this research.
Researchers have identified an entirely new type of wood that does not fit into either category of hardwood or softwood.
plant sciencesClimate changeRaymond WightmanJagiellonian UniversitySainsbury LaboratoryCambridge University Botanic GardenSchool of the Biological SciencesTulip tree in Cambridge University Botanic Garden
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Incidence of heart attacks and strokes was lower after COVID-19 vaccination
The study, published today in Nature Communications, showed that the incidence of arterial thromboses, such as heart attacks and strokes, was up to 10% lower in the 13 to 24 weeks after the first dose of a COVID-19 vaccine. Following a second dose, the incidence was up to 27% lower after receiving the AstraZeneca vaccine and up to 20% lower after the Pfizer/Biotech vaccine.
The incidence of common venous thrombotic events – mainly pulmonary embolism and lower limb deep venous thrombosis – followed a similar pattern.
Research led by the Universities of Cambridge, Bristol and Edinburgh and enabled by the British Heart Foundation (BHF) Data Science Centre at Health Data Research UK analysed de-identified health records from 46 million adults in England between 8 December 2020 and 23 January 2022. Data scientists compared the incidence of cardiovascular diseases after vaccination with the incidence before or without vaccination, during the first two years of the vaccination programme.
Co-first author Dr Samantha Ip, Research Associate at the Department of Public Health and Primary Care, University of Cambridge, said: “We studied COVID-19 vaccines and cardiovascular disease in nearly 46 million adults in England and found a similar or lower incidence of common cardiovascular diseases, such as heart attacks and strokes, following each vaccination than before or without vaccination. This research further supports the large body of evidence on the safety of the COVID-19 vaccination programme, which has been shown to provide protection against severe COVID-19 and saved millions of lives worldwide.”
Previous research found that the incidence of rare cardiovascular complications is higher after some COVID-19 vaccines. For example, incidence of myocarditis and pericarditis have been reported following mRNA-based vaccines such as the Pfizer/Biotech vaccine, and vaccine-induced thrombotic thrombocytopenia following adenovirus-based vaccines such as the AstraZeneca vaccine. This study supports these findings, but importantly it did not identify new adverse cardiovascular conditions associated with COVID-19 vaccination and offers further reassurance that the benefits of vaccination outweigh the risk.
Incidence of cardiovascular disease is higher after COVID-19, especially in severe cases. This may explain why incidence of heart attacks and strokes is lower in vaccinated people compared with unvaccinated people, but further explanations are beyond the scope of this study.
Professor William Whiteley, Associate Director at the BHF Data Science Centre and Professor of Neurology and Epidemiology at the University of Edinburgh, said: “The COVID-19 vaccination programme rollout began strongly in the UK, with over 90% of the population over the age of 12 vaccinated with at least one dose by January 2022.
“This England-wide study offers patients reassurance of the cardiovascular safety of first, second and booster doses of COVID-19 vaccines. It demonstrates that the benefits of second and booster doses, with fewer common cardiovascular events include heart attacks and strokes after vaccination, outweigh the very rare cardiovascular complications.”
The research team used de-identified linked data from GP practices, hospital admissions and death records, analysed in a secure data environment provided by NHS England.
Co-last author Dr Venexia Walker, Research Fellow at the University of Bristol, said: “Given the critical role of COVID-19 vaccines in protecting people from COVID-19, it is important we continue to study the benefits and risks associated with them. The availability of population-wide data has allowed us to study different combinations of COVID-19 vaccines and to consider rare cardiovascular complications. This would not have been possible without the very large data that we are privileged to access and our close cross-institution collaborations.”
Reference
Ip, S et al. Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England. Nat Comms; 31 Jul 2024; DOI: 10.1038/s41467-024-49634-x
Adapted from a press release from Health Data Research UK
The incidence of heart attacks and strokes was lower after COVID-19 vaccination than before or without vaccination, according to a new study involving nearly the whole adult population of England.
coronavirusCOVID-19vaccinecardiovascular disease (CVD)Samantha IpBritish Heart FoundationUniversity of BristolHealth Data Research UKSchool of Clinical MedicineDepartment of Public Health and Primary CareBHF Cambridge Centre for Cardiovascular Research ExcellenceThis research further supports the large body of evidence on the effectiveness of the COVID-19 vaccination programme, which has saved millions of lives worldwideSamantha IpPaul_McManusVial of the AstraZeneca COVID-19 vaccine
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Thousands of birds and fish threatened by mining for clean energy transition
New research has found that 4,642 species of vertebrate are threatened by mineral extraction around the world through mining and quarrying, and drilling for oil and gas.
Mining activity coincides with the world's most valuable biodiversity hotspots, which contain a hyper-diversity of species and unique habitats found nowhere else on Earth.
The biggest risk to species comes from mining for materials fundamental to our transition to clean energy, such as lithium and cobalt – both essential components of solar panels, wind turbines and electric cars.
Quarrying for limestone, which is required in huge amounts for cement as a construction material, is also putting many species at risk.
The threat to nature is not limited to the physical locations of the mines - species living at great distances away can also be impacted, for example by polluted watercourses, or deforestation for new access roads and infrastructure.
The researchers say governments and the mining industry should focus on reducing the pollution driven by mining as an ‘easy win’ to reduce the biodiversity loss associated with mineral extraction.
This is the most complete global assessment of the threat to biodiversity from mineral extraction ever undertaken. The results are published today in the journal Current Biology.
“We simply won’t be able to deliver the clean energy we need to reduce our climate impact without mining for the materials we need, and that creates a problem because we’re mining in locations that often have very high levels of biodiversity,” said Professor David Edwards in the University of Cambridge’s Department of Plant Sciences and Conservation Research Institute, senior author of the report.
He added: “So many species, particularly fish, are being put at risk through the pollution caused by mining. It would be an easy win to work on reducing this freshwater pollution so we can still get the products we need for the clean energy transition, but in a way that isn’t causing so much biodiversity loss.”
Across all vertebrate species, fish are at particularly high risk from mining (2,053 species), followed by reptiles, amphibians, birds and mammals. The level of threat seems to be linked to where a particular species lives and its lifestyle: species using freshwater habitats, and species with small ranges are particularly at risk.
“The need for limestone as a core component of construction activity also poses a real risk to wildlife. Lots of species are very restricted in where they live because they're specialised to live on limestone. A cement mine can literally take out an entire hillside - and with it these species’ homes,” said Ieuan Lamb in the University of Sheffield’s School of Biosciences, first author of the report.
The Bent-Toed Gecko, for example, is threatened by limestone quarrying in Malaysia – it only exists on a single mountain range that planned mining activity will completely destroy.
To get their results, the researchers used International Union for the Conservation of Nature (IUCN) data to see which vertebrate species are threatened by mining. By mapping the locations of these species they could investigate the types of mining that are putting species at risk, and see where the risks are particularly high.
The researchers discovered that species categorised as ‘vulnerable, endangered, or critically endangered’ are more threatened by mineral extraction than species of lesser concern.
Watercourses can be affected in many ways, and water pollution can affect hundreds of thousands of square kilometres of rivers and flood plains. Mining sand as a construction material, for example, alters patterns of water flow in rivers and wetlands, making birds like the Indian Skimmer more accessible to predators.
Mineral extraction threatens vertebrate species populations across the tropics, with hotspots in the Andes, coastal West and Central Africa, and South-East Asia – which coincide with high mine density. For example, artisanal small-scale alluvial gold mining in Ghana threatens important bird areas through environmental mercury pollution.
Global demand for metal minerals, fossil fuels and construction materials is growing dramatically, and the extraction industry is expanding rapidly to meet this demand. In 2022 the revenue of the industry as a whole was estimated at US $943 billion.
Biodiversity underpins the protection of the world’s carbon stocks, which help to mitigate climate change.
The study focused only on vertebrate species, but the researchers say mining is also likely to be a substantial risk to plants and invertebrates.
“There's no question that we are going to continue to mine - our entire societies are based on mined products. But there are environmental tensions embodied in our use of these products. Our report is a vital first step in avoiding biodiversity loss amidst the predicted drastic expansion of the mining industry,” said Edwards.
“Wildlife is more sensitive to mining in some regions of the world than in others, and our report can inform choices of where to prioritise getting our minerals to cause the least damage to biodiversity. Future policy should also focus on creating more circular economies - increasing recycling and reuse of materials, rather than just extracting more,” said Lamb.
The research was funded by the Hossein Farmy scholarship.
Reference: Lamb, I.P., ‘Global threats of extractive industries on vertebrate biodiversity.’ Current Biology, July 2024. DOI: 10.1016/j.cub.2024.06.077
Our increasing demand for metals and minerals is putting over four thousand vertebrate species at risk, with the raw materials needed for clean energy infrastructure often located in global biodiversity hotspots, a study has found.
biodiversityClimate changeMiningDavid EdwardsUniversity of SheffieldDepartment of Plant SciencesUniversity of Cambridge Conservation Research Institute (UCCRI)School of the Biological SciencesOur report is a vital first step in avoiding biodiversity loss amidst the predicted drastic expansion of the mining industry.David EdwardsGold mine in Rondonia, Amazonian Brazil
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Inside the institute looking at early cancer
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Inside the institute looking at early cancer
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Inside the institute looking at early cancer
Only 10% of lung cancer patients survive for ten or more years
Only 12% of oesophageal cancer patients survive for ten or more years
Only 12% of liver cancer patients survive ten or more years
Only 15% of acute myeloid leukaemia patients survive ten or more years
By Craig Brierley
Professor Rebecca Fitzgerald, Director of the Early Cancer Institute
Professor Rebecca Fitzgerald, Director of the Early Cancer Institute
The mission of the Li Ka Shing Early Cancer Institute at Cambridge is deceptively simple: to detect cancer early enough to cure it.The Early Cancer Institute
The Early Cancer Institute
When the Early Cancer Institute opened in 2022, it became the first physical institute in the UK dedicated to early cancer.“Traditionally, early cancer has been neglected,” says its Director, Professor Rebecca Fitzgerald. “People have been much more focused on late cancer, advanced therapies, precision therapy, for example.”
Part of the problem is the hugely expensive and long road to get a new test or preventative treatment to market. Testing a relatively small number of patients with very advanced disease in fairly small trials is a more cost effective way of seeing if a drug works; targeting early cancer, on the other hand, would involve large population studies over several years before you know if it has worked.
“People have tended to shy away from this kind of research, but I think everyone's waking up now to the fact that unless we do this, we're not going to really improve the survival for the majority of our patients, because most patients are still diagnosed late.
"Outcomes can be completely transformed – better survival and less invasive treatments – if the cancer is diagnosed early enough, but we're just hopeless at doing that. We need to find a way to do it better.”Professor Rebecca Fitzgerald
Researchers at the Institute are focusing in particular on cancers that are hard to treat and as such have very poor outcomes, including lung, pancreas, oesophagus and liver cancers, and acute myeloid leukaemia. Outcomes for these cancers have changed little over the past few years.
The cancers that defy treatment Only 5% of pancreatic cancer patients survive for ten or more yearsOnly 10% of lung cancer patients survive for ten or more years
Only 12% of oesophageal cancer patients survive for ten or more years
Only 12% of liver cancer patients survive ten or more years
Only 15% of acute myeloid leukaemia patients survive ten or more years
Lung cancer cell (Daniel Munoz-Espin)
Lung cancer cell (Daniel Munoz-Espin)
Cambridge has a history of making huge strides in cancer research, from pioneering work that led to our ability to rapidly sequence the DNA of tumours to the manufacture and use of monoclonal antibodies, a technology that now underpins routine cancer therapy globally, and the development of a new generation of cancer drugs known as PARP inhibitors.Fitzgerald’s own area of expertise is oesophageal cancer, where she pioneered the Cytosponge – a ‘pill on a string’ coupled with a lab test that is a remarkably straightforward but effective way of helping determine whether heartburn patients have Barret’s oesophagus, a pre-cursor to cancer, or are developing malignancies.
Now, she wants to build on Cambridge’s history of discovery and innovation and apply it to early cancer.
The Institute houses scientists from a broad spectrum of disciplines across the University – from biologists and clinicians to engineers, physicists and social sciences – working together under one roof to understand the fundamental biology of how cancer develops and how it evolves, and applying that knowledge to pioneer new methods for detecting, treating – even preventing – cancer early.
The Institute is located on the Cambridge Biomedical Campus, where its close proximity to a number of world-leading academic, NHS and industrial partners will prove essential to its success. These include the Cancer Research UK Cambridge Institute, the Stem Cell Institute and the Victor Phillip Dahdaleh Heart and Lung Research Institute, three hospitals, and major pharmaceutical companies AstraZeneca and GSK. At nearby West Cambridge, physicists, engineers and mathematicians will also collaborate with the Institute’s teams, and a short drive away is the Wellcome Sanger Institute.
Also on the horizon is a major new hospital on the Campus – Cambridge Cancer Research Hospital, which aims to begin construction later this year. Discoveries and innovations emerging from the Early Cancer Institute will underpin much of the research and treatment that takes place there and beyond, and will be complemented by a dedicated space in the hospital.
This is, says Fitzgerald, one of only four life sciences ecosystems in the world – and the largest in Europe – that provide the capability, critical mass, and integration of science and medicine to transform patient care.
Earlier this year, the Institute announced that it had received an anonymous £11million donation to support the redevelopment of the Hutchison building, where it is housed.
As a result of the donation, the building will be renamed the Li Ka Shing Early Cancer Institute in honour of Hong Kong-based philanthropist Sir Ka-shing Li and the enduring partnership between the Li Ka Shing Foundation and the University of Cambridge.
This donation will help Fitzgerald and colleagues achieve their ambitious goal.
“We’re working to move the world beyond the fear of cancer.”Professor Rebecca Fitzgerald
Margaret's story Heartburn – where acid from the stomach makes its way back up our oesophagus, causing a burning sensation – is a common condition and, in most cases, it is mild. But for Margaret*, a retired anaesthetist, it threatened to become something much more serious.In 2012, Margaret was referred for an endoscopy to investigate the cause of her heartburn. She was diagnosed with Barrett’s oesophagus, where long term exposure to stomach acid damages the food pipe. For the majority of people – around nine in 10 – the condition does not progress further, but for a small number of people, it can develop into oesophageal cancer.
Margaret’s specialist took a biopsy of the tissue and was able to confirm that everything was okay, but because of the risk associated with Barrett’s oesophagus, she was to receive a three-yearly check-up.
Then COVID-19 struck.
As the NHS diverted resources to manage the pandemic, waiting times for check-ups increased. 2021 came and went and Margaret wasn’t contacted for her three-yearly check-up.
“I got a call in February [2022] to say that I would have to wait longer for an endoscopy, but that they could offer me this new sponge test.”Margaret
The test used the Cytosponge, developed by Professor Rebecca Fitzgerald at the University of Cambridge. Margaret had been referred to Dr Sunny Kadri, a consultant at University Hospitals of Leicester NHS Trust and former research fellow in Professor Fitzgerald's lab conducting the initial trials of the device in 2010. It involves the patient swallowing a pill on a string. The pill dissolves to reveal a sponge, which is drawn back up the oesophagus. As it does so, it collects some of cells from the lining. It’s a procedure that takes a matter of minutes.
“It was a bit awkward to swallow, but with plenty of water goes down okay,” explains Margaret. “But it’s not as unpleasant as an endoscopy and is faster and easier, which is better for you as a patient and better for the hospital.”
The cells are stained using a laboratory marker called TFF3, allowing them to be examined under a microscope. This time, the test showed early evidence of dysplasia, a pre-cancerous stage.
Oesophageal cancer has poor outcomes – only one in eight oesophageal cancer patients (12%) survive for ten or more years, so catching the disease early is crucial. Fortunately for Margaret, the Cytosponge test had detected her condition in time for it to be treated. Dr Kadri carried out an endoscopic resection, a procedure to remove the pre-cancerous tissue. She now has three-monthly check-ups and has been told that if the dysplasia doesn’t return, it may be possible to ‘burn off’ the Barrett’s oesophagus tissue.
All this has meant that, aside from some discomfort associated with the resection treatment, Margaret is able to return to enjoying her retirement and passions of playing golf and tennis.
*Name changed at the request of the patient
DNA detectives and fossil hunters: The Early Cancer Institute's researchersProfessor Serena Nik-Zainal
Professor Serena Nik-Zainal
Professor Serena Nik-ZainalProfessor Serena Nik-Zainal is a DNA detective. She uses whole genome sequencing to investigate tumour DNA, looking for mutational signatures – or ‘fingerprints’ – that can reveal what caused the mutations in a cell’s DNA that gave rise to the cancer: was it inherited, spontaneous, or triggered by something in the environment, such as sunlight or chemicals?
“Mutational signatures are the fingerprints left behind on our DNA, and just like fingerprints, each one is unique. They allow us to treat tumours as a crime scene and, like forensic scientists, allow us to identify the culprit – and their accomplices – responsible for the tumour.”Professor Serena Nik-Zainal
Nik-Zainal has built up expertise in whole genome sequencing and analysis over the last decade or so. Now, she wants to apply this to early cancer – even to pre-cancer, for example some of the tumours that precede breast cancer, known as ductal carcinoma in situ, DCIS.
Not everybody with DCIS goes on to develop cancer, so Nik-Zainal’s team is trying to understand what sets apart those women who go on to develop cancer from those who don’t. She will be looking at whether we see the same mutational signatures in early cancers as we do in developed cancers, as this will give clues as to which signatures are important to tumour development.
At present, if a woman arrives at the clinic with a lump in her breast, she will receive a biopsy. If it turns out to be cancer, the tumour will be removed and its DNA sequenced. This is important for guiding treatment: for example, faults in inherited BRCA genes are known to put women at high risk of developing breast cancer, but tumours can develop spontaneous (or ‘somatic’) BRCA defects – whole genome sequencing of the tumour DNA will pick up these mutations and could then guide early treatment for these women.
Nik-Zainal would like to see this sequencing happen at an earlier stage: “Maybe what we should be doing is sequencing at the start, when the patient first comes to biopsy – taking that sample, sequencing it, then really understanding at that point what is the status of the genome and is there anything we can do about it sooner? We're trying to push the boundaries, make the genome sequencing matter sooner and faster.”
Dr Jamie BlundellYou might not expect to find fossil records in a cancer institute, but this is how Dr Jamie Blundell – an evolutionary biologist by training – describes the samples he works with.
His research involves looking at blood samples taken from patients with blood cancers such as acute myeloid leukaemia (AML) many years before their diagnosis.
“If I know that someone has got cancer today, but I have this kind of ‘fossil record’ of their blood samples taken over the last 20 years or so, then I can go back to the ones taken five, 10, 15 years ago and see if I can spot the earliest signs of cancer, the signs that this person was on the road to cancer.”Dr Jamie Blundell
Blundell uses insights from evolution and applies them to cancer, looking at how somatic mutations are acquired and expand.
“What we know about most cancers is that they're driven by the accumulation of multiple genetic changes on top of each other. What the samples enable you to do is essentially watch that process of evolution occurring, seeing how it unfolded in that person over the decades.”
To do this, Blundell takes the cancerous tissue and looks for the tell-tale genetic changes that gave rise to that cancer. He then tracks back through the older samples to see how and when the mutations arose, how they expanded and how they acquired further mutations.
Blood cancer is particularly suited to this approach, he says. “People don't come in and give you a chunk of liver or lung, but they will give you a blood sample. It's the one tissue where you can actually watch very precisely how cancer was born. And a lot of the work has pointed to the first mutations occurring very early on in your life, often in your teens.”
Blundell believes we are not far off being able to take blood samples from at-risk groups – over 50s, say – and look for genetic anomalies that suggest an individual is at a significantly higher risk of developing an aggressive blood cancer. These individuals could then be screened at regular intervals.
But detecting cancer early is only useful if something can be done it. Fortunately, there are experimental trials taking place in the US that might result in new treatments.
“This is where the detection and the treatment go hand in hand, because the very thing that you're using to detect it, which is the genetic change, will also inform your treatment. If you have a particular mutation in this gene, say IDH1 or IDH2, then there may be a targeted therapy for mutations in that gene, and so you can selectively target the premalignant condition.”
Dr Jamie Blundell
Dr Jamie Blundell
Dr Matt Hoare
Dr Matt Hoare
Dr Matt HoareWhile in the UK rates of most cancers are stable or declining, there is one cancer that is on the increase: primary liver cancer.
“Most people haven’t heard of primary liver cancer because historically, it's not been terribly common in this country. It's actually the fourth biggest cause of cancer related death worldwide.”Dr Matt Hoare
The reason we may not have heard about it is because liver cancer only tends to occur in individuals with liver disease, where the major risk factors have traditionally been excessive drinking and hepatitis B or C, and the latter diseases are uncommon in the UK. But there is another significant risk factor: type 2 diabetes – and cases of this disease have increased dramatically in recent years, driven by rising levels of obesity.
By the time Hoare sees liver cancer patients, he says it is often too late to treat them. “We should have caught them much, much earlier, identified that they were getting liver disease and then liver cancer.”
People in the UK with chronic liver disease are currently offered an ultrasound scan every six months, but Hoare describes this surveillance programme as “fantastically expensive, but generally ineffective”.
Like Nik-Zainal, Hoare wants to harness the revolution in genome sequencing to help understand liver cancer and who is going to develop it.
Tumours are essentially clones: a cell acquires a mutation, divides and replicates, spreading while continuing to acquire new mutations. If you sequence any part of the cancer, you should find the common mutations that led to its transformation; sequencing of non-cancerous tissue is much harder.
Working with Dr Peter Campbell from the Wellcome Sanger Institute, Hoare sequenced tissue from patients with chronic liver disease and compared this to tissue from patients with primary liver cancer, expecting to find the same mutations. But this was not the case.
“What we did find [in the case of liver disease] was lots of other mutations, and we kept seeing them again and again in the same genes and in the same parts of the same genes, which tells you that there must be Darwinian natural selection taking place.”
Just as the wing evolved independently several times – in mammals, birds and insects, for example – because it carried an evolutionary advantage, then this must also be the case with these mutations, he says: they must be overwhelmingly advantageous in liver disease.
“Why is that? What does it mean for the cancer development? At the moment we just don't know. We know they’re not cancer-causing mutations, but we keep finding them in patients who are at risk of cancer. What they actually do is they seem to affect metabolism genes, they affect things that control fat, that control diabetes, that control sugars, those kind of things. They’re not immediately obviously connected to cancer, so what's the link? That’s what we aim to find out.”
Dr Daniel Munoz-EspinWhile mutations in our DNA may drive cancer, as Dr Daniel Munoz-Espin points out, “they are not sufficient to initiate cancer”.
He is interested in emerging evidence that a tumour’s ‘microenvironment’ plays a fundamental role in cancer. The microenvironment is a tumour’s immediate surroundings: the blood vessels, immune cells, fibroblasts, for example. Understanding the changes in the microenvironment that enable the cancer to progress will be important for helping develop new ways to treat cancers.
“If we can target not only these cancer cells, but also the tumour microenvironment, we will be in a good position to develop more efficient and specific treatments.”Dr Daniel Munoz-Espin
Munoz-Espin focuses on lung cancer, and among the tools he uses are organoids – ‘mini-tumours’ grown from cancer cells that mimic the behaviour of the tumour and its microenvironment. They are increasingly used to replace the use of animals, such as mice. They can also be used to screen potential drug candidates at a scale that would neither be practical nor ethical using mice.
One particular area that Munoz-Espin is interested in is senescence, one of the ways our body responds to unrepairable damage and stress, whether that be DNA damage, activation of cancer genes or response to chemotherapy drugs, for example. “Senescence is a hot topic in cancer at the moment.”
Ordinarily, cells divide and replicate, which could be problematic if the cells are damaged. Senescence prevents the cell from dividing anymore. But it does not kill the cell, and there is increasing evidence that senescent cells can have very potent tumour-promoting activity, causing cancer initiation, progression and relapse or metastasis. This is why senescent cells are often known as ‘zombie cells’, as they are supposed to be dead, but remain very much alive.
Experimental clinical trials are underway to validate ‘senotherapies’ – a cocktail of pharmacologically-active drugs that specifically target and kill senescent cells.
“We call it a ‘one-two punch’ therapy,” says Munoz-Espin. His team is trying to identify the ideal combination for lung cancer. “We’ve found that if we eliminate senescent cells, either in the precancerous stages or after chemotherapy, then we can prevent cancer initiation and progression, significantly increasing survival rates.”
Dr Daniel Munoz-Espin
Daniel Munoz-Espin (right)
Support cancer research at CambridgeCambridge hosts a cancer research community responsible for globally significant breakthroughs and innovations.
Together we are changing the way cancer is treated. Our scientists will make discoveries alongside expert clinicians treating patients, drawing on the world-leading expertise found within the University and across the Cambridge Biomedical Campus.
We will find cancer earlier and treat it better. Join us. Donate nowThis article was first published on 21 September 2022. It was updated to include details of the £11m donation on 24 July 2024 and republished as part of the University of Cambridge's campaign Cambridge is Changing the Story of Cancer.
Photography:
- Main image of Rebecca Fitzgerald by Mike Thornton (Stillvision)
- All other images by Lloyd Mann
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TopBuilt with Shorthand { setTimeout(() => { document.querySelectorAll('#main a').forEach(link => link.classList.remove('campl-external')); }, 2050); }); //--> Summary:Today sees the launch of the Early Cancer Institute at Cambridge. Its mission is deceptively simple: to detect cancer early enough to cure it.
Image: Affiliation (schools and institutions): School of Clinical MedicineCambridge Cancer CentreEarly Cancer InstituteCancer Research UK Cambridge CentrePeople (our academics and staff): Rebecca FitzgeraldSerena Nik-ZainalMatt HoareJamie BlundellDaniel Munoz-EspinSubject (including Spotlight on ... where applicable): CancerStoriesSection: ResearchSuper Tags: Health and medicineUniversity newsShorthand Story Description/Subtitle: A new Early Cancer Institute has opened at Cambridge. Its mission is deceptively simple: to detect cancer early enough to cure it.Shorthand Story Authors: Craig BrierleyShorthand Story Thumbnail: https://www.cam.ac.uk/sites/www.cam.ac.uk/files/shorthand/234111/ZN5ozIKWwn/assets/ANXFvuTsyd/c0942_005e-land-thumbnail.jpgNew genetic test will eliminate a form of inherited blindness in dogs
Progressive retinal atrophy (PRA) is a group of inherited diseases that causes progressive degeneration of the light sensitive cells at the back of the eye. Dogs with PRA have normal sight at birth, but by the age of four or five they will be totally blind. There is no treatment.
Now a team led by the University of Cambridge has identified the genetic mutation that causes PRA in English Shepherd Dogs, and developed a DNA test for it. By identifying dogs carrying the disease before their eyesight starts to fail, this provides a tool to guide breeding decisions so the disease is not passed on to puppies.
Owners usually don’t realise their dog has PRA until it is middle-aged, by which time it might have bred, and passed on the faulty gene to its puppies. This has made it a difficult disease to control.
The new discovery means that progressive retinal atrophy can now be completely eliminated from the English Shepherd Dog population very quickly.
The results are published today in the journal Genes.
“Once the dog’s eyesight starts to fail there’s no treatment – it will end up totally blind,” said Katherine Stanbury, a researcher in the University of Cambridge’s Department of Veterinary Medicine and first author of the report.
She added: “Now we have a DNA test, there’s no reason why another English Shepherd Dog ever needs to be born with this form of progressive retinal atrophy – it gives breeders a way of totally eliminating the disease.”
The genetic mutation identified by the team is recessive, which means it only causes blindness if the English Shepherd Dog inherits two copies of it. If the dog only has one copy this makes it a carrier – it will not develop PRA but can pass the mutation on to its puppies. If two carriers are bred together, about one in four of the puppies will be affected with PRA.
Dogs breeds are very inbred, so many individuals are related – giving them a much higher chance of being affected by recessive diseases than humans.
The team began the research after being contacted by a distraught owner of an English Shepherd Dog that had been recently diagnosed with PRA. The dog had been working as a search and rescue dog but had to retire due to visual deterioration that has resulted in total blindness. The researchers put out a call for DNA samples from other owners or breeders of this breed, and received samples from six English Shepherds with PRA and twenty without it. This was enough for them to pinpoint the genetic mutation responsible for PRA using whole genome sequencing.
The team offers a commercial canine genetic testing service providing DNA tests to dog breeders to help them avoid breeding dogs that will develop inherited diseases. As part of this they will now offer a DNA test for Progressive Retinal Atrophy in English Shepherds. Anyone can buy a testing kit, costing just £48, to take a swab from inside their dog’s mouth and send it back for testing.
“An owner won't necessarily notice their dog has got anything wrong with its eyes until it starts bumping into the furniture. Unlike humans who will speak up if their sight isn’t right, dogs just have to get on with things,” said Dr Cathryn Mellersh in the University of Cambridge’s Department of Veterinary Medicine, senior author of the report.
She added: “For the price of a decent bag of dog food people can now have their English Shepherd tested for Progressive Retinal Atrophy prior to breeding. It’s about prevention, rather than a cure, and it means a huge amount to the people who breed these dogs. They no longer need to worry about whether the puppies are going to be healthy or are going to develop this horrible disease in a few years’ time.”
The English Shepherd is a breed of herding dog popular in the United States and is closely related to the Border Collie.
The new discovery is the thirty-third genetic mutation causing an inherited disease in dogs that the team has found – twenty-three of which cause eye diseases. They say that the health and wellbeing of many dogs has been compromised because of how they have been bred by humans.
PRA occurs in many dog breeds including the English Shepherd Dog. And it is similar to a disease called retinitis pigmentosa in humans, which also causes blindness. The researchers say that their work with dogs could shed light on the human version of the disease and potentially identify targets for gene therapy in the future.
The work was carried out in collaboration with Wisdom Panel, Mars Petcare, as part of the Consortium to Research Inherited Eye Diseases in Dogs (CRIEDD), with funding from the Dog’s Trust and the Kennel Club Charitable Trust.
Reference: Stanbury, K. et al, ‘Exonic SINE insertion in FAM161A is associated with autosomal recessive progressive retinal atrophy in the English Shepherd.’ July 2024.
Cambridge scientists have identified the genetic mutation that causes progressive retinal atrophy in English Shepherd Dogs, which results in incurable blindness, and developed a genetic test to help eliminate the disease from future generations of the breed.
animal healthgeneticsKatherine StanburyCathryn MellershWisdom PanelDepartment of Veterinary MedicineSchool of the Biological SciencesNow we have a DNA test, there’s no reason why another English Shepherd Dog ever needs to be born with this form of progressive retinal atrophy – it gives breeders a way of totally eliminating the disease.Katherine StanburyEnglish Shepherd puppy
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Mindfulness training may lead to altered states of consciousness, study finds
The team say that while these experiences can be very positive, that is not always the case. Mindfulness teachers and students need to be aware that they can be a side-effect of training, and students should feel empowered to share their experiences with their teacher or doctor if they have any concerns.
Mindfulness-based programmes have become very popular in recent years. According to recent surveys, 15% of adults in the UK have learnt some form of mindfulness. They are often practised as a way of reducing stress or coping with depression and anxiety. There is anecdotal evidence that practising mindfulness can lead to alterations of the senses, self, and body boundaries, some even similar to those induced by psychotropic drugs.
From September 2015 to January 2016, the University of Cambridge conducted a randomised controlled trial to assess the effectiveness of mindfulness training as a way of coping with the stress of examinations and found that it can help support students at risk of mental health problems.
Dr Julieta Galante from the Department of Psychiatry at the University of Cambridge, who led the trial, said: “There’s been anecdotal evidence that people who practice mindfulness experience changes in how they perceive themselves and the world around them, but it’s difficult to know whether these experiences are a result of mindfulness practice or whether people who are more prone to such experiences are also more likely to practise mindfulness.
“Because we’d been running a randomised trial of mindfulness practice with several hundred students at Cambridge, we realised this offered us an opportunity to explore this question further.”
The team behind the trial followed up with participants a year later to investigate whether they had experienced any of the altered states of consciousness being reported anecdotally. The results are published today in PLOS ONE.
Participants were asked to complete a questionnaire that explored 11 ‘dimensions’ such as: spiritual experience; blissful state; disembodiment; and unity. In experiences of unity there is a sense that borders dissolve and everything, sometimes including the sense of time, is perceived in an integrated way. Disembodiment experiences often consist of a floating sensation or a dissolution of body boundaries, which may facilitate strong unity experiences.
In total, 670 participants took part in the randomised trial. Around a third each from the mindfulness trial and the control arm went on to complete the questionnaire about experiences of altered states of consciousness.
The researchers found that people who had received the mindfulness training were twice as likely as those in the control group to experience unity and disembodiment.
When the researchers explored the relationship between the total hours of formal mindfulness practice and the presence and intensity of experiences of altered states of consciousness, they found that the more people practised, the more likely they were to have an experience of unity, disembodiment, or of a blissful state.
Participants who reported having meditated in the six months prior were asked if altered states of consciousness happened during meditation. Based on this sub-sample of 73 participants, 43% reported unity experiences during meditation, 47% blissful states, 29% disembodiment experiences, and 25% insightfulness experiences.
Dr Galante said: “Although we can’t say definitively, our results at least suggest the possibility that mindfulness training causes these experiences of unity and disembodiment. It aligns with other studies showing that people who practice mindfulness training are more likely to describe experiencing a sense of relaxed self-boundaries and broadening their spatial awareness beyond the physical body.”
Dr Galante, who practices mindfulness, has herself experienced these altered states of consciousness.
“I’ve benefited a lot personally from meditation and mindfulness and I’ve also had many of these experiences,” she said. “They were intense, and at first I found it difficult to share them with my meditation teacher. I didn’t know if they were normal or desirable or if they were a sign of problems with my mental health.”
While many experiences of altered states of consciousness are likely to be interpreted as pleasant, this may not always be the case, and Dr Galante says that it is important for teachers and their students to be aware that they may arise and be open to talking about them.
She added: “The most common and intense experiences tend to be those that do not have intrinsically unpleasant characteristics. Some, such as bliss, can feel extremely pleasant. But some experiences, such as disembodiment or altered sense of self could be perceived as unpleasant, or startling, even alarming, especially if you’re not expecting them.
“It’s important that people who are offered mindfulness are told about the possibility that they may come across these experiences. That way, if they do experience them, they shouldn’t be disconcerted. There may be nothing wrong with their experience, but it may be useful for them to check in with their mindfulness teacher, and if the experience was negative, to also consider discussing it with their doctor.”
The research was supported by the University of Cambridge Vice-Chancellor’s Endowment Fund, the University Counselling Service and the National Institute for Health Research (NIHR) Applied Research Collaboration East of England programme.
Reference
Galante, J & Montero-Marin, J et al. Altered states of consciousness caused by a mindfulness-based programme up to a year later: results from a randomised controlled trial. PLOS ONE; 17 July 2024; DOI: 10.1371/journal.pone.0305928
Mindfulness training may lead participants to experience disembodiment and unity – so-called altered states of consciousness – according to a new study from researchers at the University of Cambridge.
mindfulnessJulieta GalanteNIHR CLAHRC for Cambridgeshire and Peterborough NHS Foundation TrustSchool of Clinical MedicineDepartment of PsychiatryI’ve benefited a lot personally from meditation and mindfulness and I’ve also had many of these experiences. I didn’t know if they were normal or desirableJulieta GalanteDingzeyu Li Woman sitting on sand at sunset meditating
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‘Diabetes distress’ increases risk of mental health problems among young people living with type 1 diabetes
The findings highlight the urgent need for monitoring and support for the mental health of young people diagnosed with type 1 diabetes.
According to the charity JDRF, there are 8.7 million people living with type 1 diabetes around the world, including over 400,000 people in the UK. It is a chronic, life-threatening condition, usually diagnosed in childhood, that has a life-long impact.
Currently, people with type 1 diabetes rely on a routine of finger-prick blood tests and insulin injections or infusions, because their pancreas no longer produces insulin itself, although recent developments in artificial pancreas technology are helping transform this care.
Previous studies have shown potential links between childhood-onset type 1 diabetes and a number of mental health disorders in adulthood. However, it is not clear whether these links can be best explained by the impacts of living with the condition and its treatment, or whether underlying common biological mechanisms may be implicated, for example the impact of unstable blood sugar levels on the developing adolescent brain.
To help answer this question, a team of researchers turned to data from over 4,500 children with type 1 diabetes on a national register in the Czech Republic and from large-scale European DNA studies.Their findings are published today in Nature Mental Health.
From the national register data, the researchers found that children diagnosed with type 1 diabetes – compared to children without the condition – were over twice as likely to develop a mood disorder and more than 50% more likely to develop an anxiety disorder. They were also more than four times more likely to develop behavioural syndromes including eating and sleep disorders
Conversely, children with type 1 diabetes were at a much lower risk of developing psychotic disorders, such as schizophrenia – almost half the risk compared to their peers.
The findings are consistent with the results from two other national register studies in Sweden and in Denmark, suggesting that the results would likely apply to other countries, too, including the UK.
The team used a statistical technique known as Mendelian Randomisation to probe causal links between type 1 diabetes and these various psychiatric disorders, but found little evidence in support of a common underlying biological mechanism.
Tomáš Formánek, a PhD student at the University of Cambridge and the National Institute of Mental Health, Klecany, Czech Republic, said: “Although we found a concerning increase in the risk of mental health problems among people living with type 1 diabetes, our study – and others before it – suggests this is unlikely to be the result of common biological mechanisms. This emphasises the importance of prevention and sustained attention to the mental health needs of children and young people with type 1 diabetes.”
The researchers say that mental health problems in later life may be a result of children with type 1 diabetes being forced to make significant changes to their lives, with a constant focus on monitoring their food intake and a need to check blood sugar levels and administer insulin injections. This often leaves these children feeling excluded from social events and singled-out by peers, teachers and even family members.
Dr Benjamin Perry from the Department of Psychiatry, University of Cambridge, said: “We know that people diagnosed with type 1 diabetes can experience ‘diabetes distress’. This can include extreme frustration with blood sugars and feelings of isolation and can lead to burnout, hopelessness, and a feeling of lack of control. It’s little wonder, then, that they are at risk of compounding mental health problems, spanning into their adult lives.”
Professor Peter Jones, also from the Department of Psychiatry, University of Cambridge, added: “Our findings emphasise the urgent need to support children diagnosed with type 1 diabetes, look out for signs of mental health problems and offer timely, expert help. That way, it may be possible to help these children early, before these problems fully take root.”
The research was supported by the National Institute for Health and Care Research Applied Research Collaboration East of England at Cambridgeshire and Peterborough NHS Foundation Trust and the Ministry of Health, Czech Republic, with additional funding from Wellcome and the UKRI Medical Research Council.
Reference
Formánek, T et al. Childhood-Onset Type 1 Diabetes and Subsequent Adult Psychiatric Disorders: A Nationwide Cohort and Genome-wide Mendelian Randomization Study. Nature Mental Health; 17 July 2024; DOI: 10.1038/s44220-024-00280-8
Children diagnosed with type 1 diabetes are at significantly higher risk of a number of mental health issues, including mood and anxiety disorders, a study from a team in the UK and the Czech Republic has found.
childrendiabetesMental healthTomáš FormánekBenjamin PerryPeter JonesNational Institute for Health Research (NIHR) Applied Research Collaboration East of EnglandWellcomeMedical Research CouncilSchool of Clinical MedicineDepartment of PsychiatryWe know that people diagnosed with type 1 diabetes can experience ‘diabetes distress’. It’s little wonder, then, that they are at risk of compounding mental health problems, spanning into their adult livesBenjamin PerrykyotokushigeTeenager With Type 1 Diabetes Takes at Home Test
The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.